| Literature DB >> 33966217 |
O Semyachkina-Glushkovskaya1, D Bragin2,3, O Bragina2, Y Yang4, A Abdurashitov5, A Esmat5, A Khorovodov5, A Terskov5, M Klimova5, I Agranovich5, I Blokhina5, A Shirokov6, N Navolokin7, V Tuchin5, J Kurths5,8,9.
Abstract
The blood-brain barrier (BBB) poses a significant challenge for drug delivery to the brain. The limitations of our knowledge about the nature of BBB explain the slow progress in the therapy of brain diseases and absence of methods for drug delivery to the brain in clinical practice. Here, we show that the BBB opens for high-molecular-weight compounds after exposure to loud sound (100 dB 370 Hz) in rats. The role of stress induced by loud sound and the systemic and molecular mechanisms behind it are discussed in the framework of the BBB. This opens an informative platform for novel fundamental knowledge about the nature of BBB and for the development of a noninvasive brain drug delivery technology.Entities:
Keywords: Blood-brain barrier; Cerebral blood oxygen saturation; Loud sound; Mechanisms; Meningeal lymphatic clearance
Mesh：
Year: 2021 PMID： 33966217 PMCID： PMC9131853 DOI： 10.1007/978-3-030-48238-1_31
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 3.650