Joydeep Ghosh1, Roy El Koussa2, Safa F Mohamad3, Jianyun Liu1, Melissa A Kacena4,5, Edward F Srour1,2,6. 1. Department of Medicine. 2. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana. 3. Department of Hematology/Oncology, Boston Children's Hospital, Harvard University, Boston, Massachusetts. 4. Department of Orthopaedic Surgery. 5. Department of Anatomy, Cell Biology and Physiology. 6. Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Abstract
PURPOSE OF REVIEW: Development and functions of hematopoietic stem cells (HSC) are regulated by multiple cellular components of the hematopoietic niche. Here we review the recent advances in studying the role of three such components -- osteoblasts, osteomacs, and megakaryocytes and how they interact with each other in the hematopoietic niche to regulate HSC. RECENT FINDINGS: Recent advances in transgenic mice models, scRNA-seq, transcriptome profile, proteomics, and live animal imaging have revealed the location of HSC within the bone and signaling molecules required for the maintenance of the niche. Interaction between megakaryocytes, osteoblasts and osteomacs enhances hematopoietic stem and progenitor cells (HSPC) function. Studies also revealed the niche as a dynamic entity that undergoes cellular and molecular changes in response to stress. Aging, which results in reduced HSC function, is associated with a decrease in endosteal niches and osteomacs as well as reduced HSC--megakaryocyte interactions. SUMMARY: Novel approaches to study the cellular components of the niche and their interactions to regulate HSC development and functions provided key insights about molecules involved in the maintenance of the hematopoietic system. Furthermore, these studies began to build a more comprehensive model of cellular interactions and dynamics in the hematopoietic niche.
PURPOSE OF REVIEW: Development and functions of hematopoietic stem cells (HSC) are regulated by multiple cellular components of the hematopoietic niche. Here we review the recent advances in studying the role of three such components -- osteoblasts, osteomacs, and megakaryocytes and how they interact with each other in the hematopoietic niche to regulate HSC. RECENT FINDINGS: Recent advances in transgenic mice models, scRNA-seq, transcriptome profile, proteomics, and live animal imaging have revealed the location of HSC within the bone and signaling molecules required for the maintenance of the niche. Interaction between megakaryocytes, osteoblasts and osteomacs enhances hematopoietic stem and progenitor cells (HSPC) function. Studies also revealed the niche as a dynamic entity that undergoes cellular and molecular changes in response to stress. Aging, which results in reduced HSC function, is associated with a decrease in endosteal niches and osteomacs as well as reduced HSC--megakaryocyte interactions. SUMMARY: Novel approaches to study the cellular components of the niche and their interactions to regulate HSC development and functions provided key insights about molecules involved in the maintenance of the hematopoietic system. Furthermore, these studies began to build a more comprehensive model of cellular interactions and dynamics in the hematopoietic niche.
Authors: Wendy W Pang; Elizabeth A Price; Debashis Sahoo; Isabel Beerman; William J Maloney; Derrick J Rossi; Stanley L Schrier; Irving L Weissman Journal: Proc Natl Acad Sci U S A Date: 2011-11-28 Impact factor: 11.205
Authors: Benjamin J Frisch; Corey M Hoffman; Sarah E Latchney; Mark W LaMere; Jason Myers; John Ashton; Allison J Li; Jerry Saunders; James Palis; Archibald S Perkins; Amanda McCabe; Julianne Np Smith; Kathleen E McGrath; Fatima Rivera-Escalera; Andrew McDavid; Jane L Liesveld; Vyacheslav A Korshunov; Michael R Elliott; Katherine C MacNamara; Michael W Becker; Laura M Calvi Journal: JCI Insight Date: 2019-04-18
Authors: L M Calvi; G B Adams; K W Weibrecht; J M Weber; D P Olson; M C Knight; R P Martin; E Schipani; P Divieti; F R Bringhurst; L A Milner; H M Kronenberg; D T Scadden Journal: Nature Date: 2003-10-23 Impact factor: 49.962
Authors: Jing Zhang; Joydeep Ghosh; Safa F Mohamad; Chi Zhang; Xinxin Huang; Maegan L Capitano; Andrea M Gunawan; Scott Cooper; Bin Guo; Qingchun Cai; Hal E Broxmeyer; Edward F Srour Journal: Stem Cells Date: 2019-08-14 Impact factor: 5.845