Literature DB >> 33965976

The Impact of Insulin Resistance on Cardiovascular Control During Exercise in Diabetes.

Masaki Mizuno, Norio Hotta, Rie Ishizawa1, Han-Kyul Kim2, Gary Iwamoto3, Wanpen Vongpatanasin2, Jere H Mitchell2, Scott A Smith.   

Abstract

Patients with diabetes display heightened blood pressure response to exercise, but the underlying mechanism remains to be elucidated. There is no direct evidence that insulin resistance (hyperinsulinemia or hyperglycemia) impacts neural cardiovascular control during exercise. We propose a novel paradigm in which hyperinsulinemia or hyperglycemia significantly influences neural regulatory pathways controlling the circulation during exercise in diabetes.
Copyright © 2021 by the American College of Sports Medicine.

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Year:  2021        PMID: 33965976      PMCID: PMC8195845          DOI: 10.1249/JES.0000000000000259

Source DB:  PubMed          Journal:  Exerc Sport Sci Rev        ISSN: 0091-6331            Impact factor:   6.642


  129 in total

Review 1.  Intranasal administration of insulin to the brain impacts cognitive function and peripheral metabolism.

Authors:  V Ott; C Benedict; B Schultes; J Born; M Hallschmid
Journal:  Diabetes Obes Metab       Date:  2011-11-16       Impact factor: 6.577

Review 2.  Static (isometric) exercise and the heart: physiological and clinical considerations.

Authors:  J H Mitchell; K Wildenthal
Journal:  Annu Rev Med       Date:  1974       Impact factor: 13.739

3.  Expression and localization of insulin receptor in rat dorsal root ganglion and spinal cord.

Authors:  Kazuhiro Sugimoto; Yuichi Murakawa; Anders A F Sima
Journal:  J Peripher Nerv Syst       Date:  2002-03       Impact factor: 3.494

4.  Glutamate receptors in the hypothalamic paraventricular nucleus contribute to insulin-induced sympathoexcitation.

Authors:  Sean D Stocker; Kathryn W Gordon
Journal:  J Neurophysiol       Date:  2014-12-04       Impact factor: 2.714

5.  Intracerebroventricular insulin produces nonuniform regional increases in sympathetic nerve activity.

Authors:  M S Muntzel; D A Morgan; A L Mark; A K Johnson
Journal:  Am J Physiol       Date:  1994-11

6.  Patients with type 2 diabetes have exaggerated brachial and central exercise blood pressure: relation to left ventricular relative wall thickness.

Authors:  James A Scott; Jeff S Coombes; Johannes B Prins; Rodel L Leano; Thomas H Marwick; James E Sharman
Journal:  Am J Hypertens       Date:  2008-04-17       Impact factor: 2.689

7.  The mechano-gated channel inhibitor GsMTx4 reduces the exercise pressor reflex in decerebrate rats.

Authors:  Steven W Copp; Joyce S Kim; Victor Ruiz-Velasco; Marc P Kaufman
Journal:  J Physiol       Date:  2016-01-05       Impact factor: 5.182

8.  Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells.

Authors:  Etsuko Hisanaga; Masahiro Nagasawa; Kohjiro Ueki; Rohit N Kulkarni; Masatomo Mori; Itaru Kojima
Journal:  Diabetes       Date:  2008-11-04       Impact factor: 9.461

9.  Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes.

Authors:  S Devaraj; M R Dasu; S H Park; I Jialal
Journal:  Diabetologia       Date:  2009-05-20       Impact factor: 10.122

10.  Sensory neuronal sensitisation occurs through HMGB-1-RAGE and TRPV1 in high-glucose conditions.

Authors:  Samuel M Bestall; Richard P Hulse; Zoe Blackley; Matthew Swift; Nikita Ved; Kenneth Paton; Nicholas Beazley-Long; David O Bates; Lucy F Donaldson
Journal:  J Cell Sci       Date:  2018-07-26       Impact factor: 5.285

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  1 in total

1.  Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents.

Authors:  Amane Hori; Norio Hotta; Ayumi Fukazawa; Juan A Estrada; Kimiaki Katanosaka; Kazue Mizumura; Jun Sato; Rie Ishizawa; Han-Kyul Kim; Gary A Iwamoto; Wanpen Vongpatanasin; Jere H Mitchell; Scott A Smith; Masaki Mizuno
Journal:  J Physiol       Date:  2022-01-13       Impact factor: 6.228

  1 in total

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