Aiko Iwase1, Makoto Fujii2, Hiroshi Murata3, Yuko Ohno2, Makoto Araie4. 1. From the Tajimi Iwase Eye Clinic, Gifu, Japan (A.I.). Electronic address: aiko-gif@umin.net. 2. Division of Health and Sciences (M.F., Y.O.), Osaka University Graduate School of Medicine, Osaka, Japan. 3. Department of Ophthalmology (HM), University of Tokyo Graduate School of Medicine, Tokyo, Japan. 4. and the Kanto Central Hospital of The Mutual Aid Association of Public School Teachers (M.A.), Tokyo, Japan.
Abstract
PURPOSE: The purpose of this study was to investigate how mild-to-moderate myopia and aging affect visual field sensitivity (VF-S) in normal eyes, correcting for effects of each. DESIGN: Combined cross-sectional and cohort study. METHODS: Two normal groups, a cross-sectional group (n = 703; 1,051 eyes; mean age, 52.6 years) and a longitudinal group (n = 44; 83 eyes; mean age, 52.3 years; follow-up, 4.2 years; VF tests, 12) were included. In the cross-sectional group, the mean VF-S of the entire field and 3 disc portion-oriented subfields of the Humphrey Field Analyzer 24-2 program were correlated with subjects' age, axial length (AL), disc, rim and β-peripapillary area, and disc ovality and torsion, using linear mixed-regression models. Their time changes in the longitudinal group were correlated with time, subjects' ages, and AL using linear mixed-regression models. RESULTS: In the cross-sectional group, the VF-S correlated negatively with age (-0.081 decibel [dB]/year; P < .001), which was more negative (P = .020) in the midperipheral than the central subfield, and with AL (P = .049) without intersubfield differences. In the longitudinal group, no changes in the ocular media were significant, and the VF-S declined by 0.074 dB/year (P = .007), which accelerated with higher age (P < .002) and baseline VF-S (P < .001) without intersubfield differences. The AL showed little effects on the VF-S longitudinal changes. CONCLUSIONS: In normal eyes with mild-to-moderate myopia, the VF-S was lower subfield-independently with longer AL, whereas the AL had little effect on the aging-associated VF-S reduction. The VF-S decreased with aging with intersubfield differences. The aging-associated VF-S reduction accelerated with higher age, to which the ocular media changes were unrelated.
PURPOSE: The purpose of this study was to investigate how mild-to-moderate myopia and aging affect visual field sensitivity (VF-S) in normal eyes, correcting for effects of each. DESIGN: Combined cross-sectional and cohort study. METHODS: Two normal groups, a cross-sectional group (n = 703; 1,051 eyes; mean age, 52.6 years) and a longitudinal group (n = 44; 83 eyes; mean age, 52.3 years; follow-up, 4.2 years; VF tests, 12) were included. In the cross-sectional group, the mean VF-S of the entire field and 3 disc portion-oriented subfields of the Humphrey Field Analyzer 24-2 program were correlated with subjects' age, axial length (AL), disc, rim and β-peripapillary area, and disc ovality and torsion, using linear mixed-regression models. Their time changes in the longitudinal group were correlated with time, subjects' ages, and AL using linear mixed-regression models. RESULTS: In the cross-sectional group, the VF-S correlated negatively with age (-0.081 decibel [dB]/year; P < .001), which was more negative (P = .020) in the midperipheral than the central subfield, and with AL (P = .049) without intersubfield differences. In the longitudinal group, no changes in the ocular media were significant, and the VF-S declined by 0.074 dB/year (P = .007), which accelerated with higher age (P < .002) and baseline VF-S (P < .001) without intersubfield differences. The AL showed little effects on the VF-S longitudinal changes. CONCLUSIONS: In normal eyes with mild-to-moderate myopia, the VF-S was lower subfield-independently with longer AL, whereas the AL had little effect on the aging-associated VF-S reduction. The VF-S decreased with aging with intersubfield differences. The aging-associated VF-S reduction accelerated with higher age, to which the ocular media changes were unrelated.