Darel Wee Kiat Toh1, Xuejuan Xia1, Clarinda Nataria Sutanto1, Jasmine Hui Min Low1, Kian Keong Poh2,3, Jiong-Wei Wang4,5,6, Roger Sik-Yin Foo4,7, Jung Eun Kim1. 1. Department of Food Science & Technology, Faculty of Science, National University of Singapore, Singapore, Singapore. 2. Department of Cardiology, National University Heart Centre, Singapore, Singapore. 3. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 4. Cardiovascular Research Institute, National University Health Systems, Centre for Translational Medicine, Singapore, Singapore. 5. Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 6. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. 7. Genome Institute of Singapore, Singapore, Singapore.
Abstract
BACKGROUND: The consumption of wolfberry (Lycium barbarum), a rich source of carotenoids and bioactive polysaccharides, may serve as a potential dietary strategy for cardiovascular disease (CVD) risk management although limited studies examined its effects as whole fruits. OBJECTIVES: To investigate the impact of wolfberry consumption as part of a healthy dietary pattern on vascular health-related outcomes and classical CVD risk factors in middle-aged and older adults in Singapore. METHODS: This is a 16-week, parallel design, randomized controlled trial. All participants (n = 40) received dietary counselling to follow healthy dietary pattern recommendations with the wolfberry group given additional instructions to cook and consume 15 g/d whole, dried wolfberry with their main meals. Biomarkers of vascular function (flow-mediated dilation, plasma total nitrate/nitrite, endothelin-1, and intercellular adhesion molecule-1), vascular structure (carotid intima-media thickness) and vascular regeneration (endothelial progenitor cell count, plasma angiopoietin 1 and angiopoietin 2), were assessed at baseline and postintervention. Serum lipid-lipoproteins and blood pressure were evaluated every 4 weeks. RESULTS: All participants showed an improved compliance toward the healthy dietary pattern. This was coupled with marked rises in total nitrate/nitrite concentrations (mean change wolfberry: 3.92 ± 1.73 nmol/mL; control: 5.01 ± 2.55 nmol/L) and reductions in endothelin-1 concentrations (wolfberry: -0.19 ± 0.06 pg/mL; control: -0.15 ± 0.08 pg/mL). Compared with the control which depicted no changes from baseline, the wolfberry group had a significantly higher HDL cholesterol (0.08 ± 0.04 mmol/L), as well as lower Framingham predicted long-term CVD risk (-0.8 ± 0.5%) and vascular age (-1.9 ± 1.0 y) postintervention. No differences were observed in the other vascular health-related outcomes. CONCLUSIONS: In middle-aged and older adults, adherence to a healthy dietary pattern improves vascular tone. Incorporating wolfberry to the diet further improves blood lipid-lipoprotein profile and may lower long-term CVD risk. This study was registered at clinicatrials.gov as NCT03535844.
RCT Entities:
BACKGROUND: The consumption of wolfberry (Lycium barbarum), a rich source of carotenoids and bioactive polysaccharides, may serve as a potential dietary strategy for cardiovascular disease (CVD) risk management although limited studies examined its effects as whole fruits. OBJECTIVES: To investigate the impact of wolfberry consumption as part of a healthy dietary pattern on vascular health-related outcomes and classical CVD risk factors in middle-aged and older adults in Singapore. METHODS: This is a 16-week, parallel design, randomized controlled trial. All participants (n = 40) received dietary counselling to follow healthy dietary pattern recommendations with the wolfberry group given additional instructions to cook and consume 15 g/d whole, dried wolfberry with their main meals. Biomarkers of vascular function (flow-mediated dilation, plasma total nitrate/nitrite, endothelin-1, and intercellular adhesion molecule-1), vascular structure (carotid intima-media thickness) and vascular regeneration (endothelial progenitor cell count, plasma angiopoietin 1 and angiopoietin 2), were assessed at baseline and postintervention. Serum lipid-lipoproteins and blood pressure were evaluated every 4 weeks. RESULTS: All participants showed an improved compliance toward the healthy dietary pattern. This was coupled with marked rises in total nitrate/nitrite concentrations (mean change wolfberry: 3.92 ± 1.73 nmol/mL; control: 5.01 ± 2.55 nmol/L) and reductions in endothelin-1 concentrations (wolfberry: -0.19 ± 0.06 pg/mL; control: -0.15 ± 0.08 pg/mL). Compared with the control which depicted no changes from baseline, the wolfberry group had a significantly higher HDL cholesterol (0.08 ± 0.04 mmol/L), as well as lower Framingham predicted long-term CVD risk (-0.8 ± 0.5%) and vascular age (-1.9 ± 1.0 y) postintervention. No differences were observed in the other vascular health-related outcomes. CONCLUSIONS: In middle-aged and older adults, adherence to a healthy dietary pattern improves vascular tone. Incorporating wolfberry to the diet further improves blood lipid-lipoprotein profile and may lower long-term CVD risk. This study was registered at clinicatrials.gov as NCT03535844.
Authors: Celia Martinez-Perez; Lidia Daimiel; Cristina Climent-Mainar; Miguel Ángel Martínez-González; Jordi Salas-Salvadó; Dolores Corella; Helmut Schröder; Jose Alfredo Martinez; Ángel M Alonso-Gómez; Julia Wärnberg; Jesús Vioque; Dora Romaguera; José López-Miranda; Ramón Estruch; Francisco J Tinahones; José Lapetra; Lluis Serra-Majem; Aurora Bueno-Cavanillas; Josep A Tur; Vicente Martín Sánchez; Xavier Pintó; Miguel Delgado-Rodríguez; Pilar Matía-Martín; Josep Vidal; Clotilde Vázquez; Emilio Ros; Javier Basterra; Nancy Babio; Patricia Guillem-Saiz; María Dolores Zomeño; Itziar Abete; Jessica Vaquero-Luna; Francisco Javier Barón-López; Sandra Gonzalez-Palacios; Jadwiga Konieczna; Antonio Garcia-Rios; María Rosa Bernal-López; José Manuel Santos-Lozano; Maira Bes-Rastrollo; Nadine Khoury; Carmen Saiz; Karla Alejandra Pérez-Vega; María Angeles Zulet; Lucas Tojal-Sierra; Zenaida Vázquez Ruiz; Maria Angeles Martinez; Mireia Malcampo; José M Ordovás; Rodrigo San-Cristobal Journal: Int J Behav Nutr Phys Act Date: 2022-01-24 Impact factor: 6.457
Authors: Bojana B Vidović; Danijel D Milinčić; Mirjana D Marčetić; Jelena D Djuriš; Tijana D Ilić; Aleksandar Ž Kostić; Mirjana B Pešić Journal: Antioxidants (Basel) Date: 2022-01-27