| Literature DB >> 33964448 |
Xiao-Lei Qi1, Heeji Jo2, Xue-Ying Wang1, Tong-Tong Ji1, Hai-Xia Lin1, Chul-Seung Park3, Yong-Mei Cui4.
Abstract
A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring.Entities:
Keywords: BK channels; Openers; SAR; Synthesis; Thiazole
Year: 2021 PMID： 33964448 DOI： 10.1016/j.bmcl.2021.128083
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823