Xuming Chen1, Shanlin Sun2, Narisu Bai3, Kun Han3, Qianqian Liu1, Shengyu Yao1, Hao Tang4, Chupeng Zhang3, Zhipeng Lu3, Qian Huang1, Guoqi Zhao1, Yi Xu1, Tingfeng Chen1, Xiaohui Xie5, Yong Liu6. 1. Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2. DeepVoxel Inc., Irvine, USA; Department of Computer Science, University of California, Irvine, USA. 3. DeepVoxel Inc., Irvine, USA. 4. Department of Computer Science, University of California, Irvine, USA. 5. Department of Computer Science, University of California, Irvine, USA. Electronic address: xhx@ics.uci.edu. 6. Department of Radiation Oncology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: yong.liu2@shgh.cn.
Abstract
BACKGROUND AND PURPOSE: Delineating organs at risk (OARs) on computed tomography (CT) images is an essential step in radiation therapy; however, it is notoriously time-consuming and prone to inter-observer variation. Herein, we report a deep learning-based automatic segmentation (AS) algorithm (WBNet) that can accurately and efficiently delineate all major OARs in the entire body directly on CT scans. MATERIALS AND METHODS: We collected 755 CT scans of the head and neck, thorax, abdomen, and pelvis and manually delineated 50 OARs on the CT images. The CT images with contours were split into training and test sets consisting of 505 and 250 cases, respectively, to develop and validate WBNet. The volumetric Dice similarity coefficient (DSC) and 95th-percentile Hausdorff distance (95% HD) were calculated to evaluate delineation quality for each OAR. We compared the performance of WBNet with three AS algorithms: one commercial multi-atlas-based automatic segmentation (ABAS) software, and two deep learning-based AS algorithms, namely, AnatomyNet and nnU-Net. We have also evaluated the time saving and dose accuracy of WBNet. RESULTS: WBNet achieved average DSCs of 0.84 and 0.81 on in-house and public datasets, respectively, which outperformed ABAS, AnatomyNet, and nnU-Net. WBNet could reduce the delineation time significantly and perform well in treatment planning, with clinically acceptable dose differences compared with those in manual delineation. CONCLUSION: This study shows the feasibility and benefits of using WBNet in clinical practice.
BACKGROUND AND PURPOSE: Delineating organs at risk (OARs) on computed tomography (CT) images is an essential step in radiation therapy; however, it is notoriously time-consuming and prone to inter-observer variation. Herein, we report a deep learning-based automatic segmentation (AS) algorithm (WBNet) that can accurately and efficiently delineate all major OARs in the entire body directly on CT scans. MATERIALS AND METHODS: We collected 755 CT scans of the head and neck, thorax, abdomen, and pelvis and manually delineated 50 OARs on the CT images. The CT images with contours were split into training and test sets consisting of 505 and 250 cases, respectively, to develop and validate WBNet. The volumetric Dice similarity coefficient (DSC) and 95th-percentile Hausdorff distance (95% HD) were calculated to evaluate delineation quality for each OAR. We compared the performance of WBNet with three AS algorithms: one commercial multi-atlas-based automatic segmentation (ABAS) software, and two deep learning-based AS algorithms, namely, AnatomyNet and nnU-Net. We have also evaluated the time saving and dose accuracy of WBNet. RESULTS: WBNet achieved average DSCs of 0.84 and 0.81 on in-house and public datasets, respectively, which outperformed ABAS, AnatomyNet, and nnU-Net. WBNet could reduce the delineation time significantly and perform well in treatment planning, with clinically acceptable dose differences compared with those in manual delineation. CONCLUSION: This study shows the feasibility and benefits of using WBNet in clinical practice.
Authors: Asma Amjad; Jiaofeng Xu; Dan Thill; Colleen Lawton; William Hall; Musaddiq J Awan; Monica Shukla; Beth A Erickson; X Allen Li Journal: Med Phys Date: 2022-02-07 Impact factor: 4.071
Authors: Alba Magallon-Baro; Maaike T W Milder; Patrick V Granton; Wilhelm den Toom; Joost J Nuyttens; Mischa S Hoogeman Journal: Front Oncol Date: 2022-06-08 Impact factor: 5.738
Authors: Gerard M Walls; Valentina Giacometti; Aditya Apte; Maria Thor; Conor McCann; Gerard G Hanna; John O'Connor; Joseph O Deasy; Alan R Hounsell; Karl T Butterworth; Aidan J Cole; Suneil Jain; Conor K McGarry Journal: Phys Imaging Radiat Oncol Date: 2022-07-26