Prashant N Rao1, Ojas Mainkar1, Nitin Bansal1, Neal Rakesh1, Paul Haffey1, Ivan Urits2,3, Vwaire Orhurhu4, Alan D Kaye3, Richard D Urman5, Amitabh Gulati6, Mark Jones7. 1. Department of Anesthesiology, New York-Presbyterian, Weill Cornell Medical College, 525 East 68th Street, Box 124, New York, NY, 10065, USA. 2. Southcoast Health, Southcoast Health Physicians Group, New Bedford, MA, USA. 3. Department of Anesthesiology, Louisiana State University Health Shreveport, Shreveport, LA, USA. 4. Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 5. Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. 6. Memorial Sloan Kettering Cancer Center, New York, NY, USA. 7. Department of Anesthesiology, New York-Presbyterian, Weill Cornell Medical College, 525 East 68th Street, Box 124, New York, NY, 10065, USA. mrj9011@nyp.org.
Abstract
PURPOSE OF REVIEW: Chronic pain continues to present a large burden to the US healthcare system. Neuropathic pain, a common class of chronic pain, remains particularly difficult to treat despite extensive research efforts. Current pharmacologic regimens exert limited efficacy and wide, potentially dangerous side effect profiles. This review provides a comprehensive, preclinical evaluation of the literature regarding the role of flavonoids in the treatment of neuropathic pain. RECENT FINDINGS: Flavonoids are naturally occurring compounds, found in plants and various dietary sources, which may have potential benefit in neuropathic pain. Numerous animal-model studies have demonstrated this benefit, including reversal of hyperalgesia and allodynia. Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-α, NF-κB, IL-1β, and IL-6. Flavonoids represent a potentially new treatment modality for neuropathic pain in preclinical models, though human clinical evidence is yet to be explored at this time.
PURPOSE OF REVIEW: Chronic pain continues to present a large burden to the US healthcare system. Neuropathic pain, a common class of chronic pain, remains particularly difficult to treat despite extensive research efforts. Current pharmacologic regimens exert limited efficacy and wide, potentially dangerous side effect profiles. This review provides a comprehensive, preclinical evaluation of the literature regarding the role of flavonoids in the treatment of neuropathic pain. RECENT FINDINGS:Flavonoids are naturally occurring compounds, found in plants and various dietary sources, which may have potential benefit in neuropathic pain. Numerous animal-model studies have demonstrated this benefit, including reversal of hyperalgesia and allodynia. Flavonoids have also exhibited an anti-inflammatory effect relevant to neuropathic pain, as evidenced by the reduction in multiple pro-inflammatory mediators, such as TNF-α, NF-κB, IL-1β, and IL-6. Flavonoids represent a potentially new treatment modality for neuropathic pain in preclinical models, though human clinical evidence is yet to be explored at this time.
Authors: Peter Gál; Jan Brábek; Michal Holub; Milan Jakubek; Aleksi Šedo; Lukáš Lacina; Karolína Strnadová; Petr Dubový; Helena Hornychová; Aleš Ryška; Karel Smetana Journal: Histochem Cell Biol Date: 2022-07-22 Impact factor: 2.531