Kamrul Islam1, Aaron J Heffernan1,2, Saiyuri Naicker1, Andrew Henderson3,4, Mohammed Abul Hassan Chowdhury5, Jason A Roberts1,3,6,7, Fekade B Sime1,3. 1. Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, 4103, Australia. 2. School of Medicine, Griffith University, Southport, Queensland, 4215, Australia. 3. University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane, QLD, 4029, Australia. 4. Infection Management Services, Princess Alexandra Hospital, Brisbane, QLD, 4103, Australia. 5. Bangladesh Institute of Tropical & Infectious Diseases (BITID), Fouzderhat, Chittagong, 4317, Bangladesh. 6. Department of Intensive Care Medicine & Pharmacy Department, Royal Brisbane & Women's Hospital, Brisbane, QLD, 4029, Australia. 7. Division of Anaesthesiology Critical Care Emergency & Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, 30029, France.
Abstract
Aim: To determine the prevalence of extended-spectrum β-lactamase (ESBL) and metallo-β-lactamase (MBL)-producing Escherichia coli in South Asia. Methodology: A systematic review and meta-analysis of data published in PubMed, EMBASE, Web of Science and Scopus. Results: The pooled prevalence of ESBL and MBL-producing E. coli in South Asia were 33% (95% CI: 27-40%) and 17% (95% CI: 12-24%), respectively. The prevalence of blaCTX-M type was 58% (95% CI: 49-66%) with blaCTX-M-15 being the most prevalent (51%, 95% CI: 40-62%) variant. The most prevalent MBL variant was blaNDM-1 (33%, 95% CI: 20-50%). Conclusion: This study suggests a high prevalence of ESBLs and MBLs among E. coli clinical isolates. Comprehensive resistance surveillance is required to guide clinicians prescribing antibiotics in South Asia.
Aim: To determine the prevalence of extended-spectrum β-lactamase (ESBL) and metallo-β-lactamase (MBL)-producing Escherichia coli in South Asia. Methodology: A systematic review and meta-analysis of data published in PubMed, EMBASE, Web of Science and Scopus. Results: The pooled prevalence of ESBL and MBL-producing E. coli in South Asia were 33% (95% CI: 27-40%) and 17% (95% CI: 12-24%), respectively. The prevalence of blaCTX-M type was 58% (95% CI: 49-66%) with blaCTX-M-15 being the most prevalent (51%, 95% CI: 40-62%) variant. The most prevalent MBL variant was blaNDM-1 (33%, 95% CI: 20-50%). Conclusion: This study suggests a high prevalence of ESBLs and MBLs among E. coli clinical isolates. Comprehensive resistance surveillance is required to guide clinicians prescribing antibiotics in South Asia.
Entities:
Keywords:
Escherichia coli; South Asia; extended-spectrum β-lactamase; meta-analysis; metallo-β-lactamase; prevalence
Authors: Kamrul Islam; Fekade B Sime; Steven C Wallis; Michelle J Bauer; Saiyuri Naicker; Hayoung Won; Hosam M Zowawi; Md Abu Choudhury; Tahmina Shirin; Zakir H Habib; Patrick N A Harris; Meerjady S Flora; Jason A Roberts Journal: Antimicrob Agents Chemother Date: 2022-08-04 Impact factor: 5.938
Authors: Kamrul Islam; Fekade B Sime; Steven C Wallis; Michelle J Bauer; Brian M Forde; Patrick Harris; Tahmina Shirin; Zakir H Habib; Meerjady S Flora; Jason A Roberts Journal: J Antimicrob Chemother Date: 2022-08-25 Impact factor: 5.758