Manuel Batram1, Julian Witte2, Magdalena Schwarz3, Johannes Hain3, Bernhard Ultsch3, Maren Steinmann2, Amit Bhavsar4, Peter Wutzler5, Carl-Peter Criée6, Christiane Hermann7, Klaus Wahle8, Martin Füchtenbusch9,10, Wolfgang Greiner2. 1. Department for Economics, Bielefeld University, P.O. Box 100131, 33501, Bielefeld, Germany. mbatram@uni-bielefeld.de. 2. Department for Health Economics and Health Care Management, Bielefeld University, Universitätsstrasse 25, 33615, Bielefeld, Germany. 3. GSK, Prinzregentenplatz 9, 81675, Munich, Germany. 4. , GSK, Avenue Fleming 20, 1300, Wavre, Belgium. 5. Section of Experimental Virology, Institute of Medical Microbiology, University-Hospital Jena, 07740, Jena, Germany. 6. Department of Sleep and Respiratory Medicine, Evangelical Hospital Goettingen-Weende, 37120, Bovenden, Germany. 7. Department of Clinical Psychology, Justus-Liebig University Giessen, Otto-Behaghel-Strasse 10F, 35394, Giessen, Germany. 8. Department of General Medicine, University of Muenster, Domagkstr. 3, 48129, Muenster, Germany. 9. Diabeteszentrum am Marienplatz, Rindermarkt 3, 80331, Munich, Germany. 10. Forschergruppe Diabetes E.V. am Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Munich-Neuherberg, Germany.
Abstract
INTRODUCTION: Several chronic underlying conditions (UCs) are known to be risk factors for developing herpes zoster (HZ) and to increase the severity of HZ and its risk of recurrence. The aim of this study was to investigate the incidence and recurrence of HZ in adult patients with one or multiple UCs. METHODS: A retrospective cohort study based on claims data representing 13% of the statutory health insurance population from 2007 to 2018 in Germany was performed. Patients aged ≥ 18 years were included when at least one of the following UCs was diagnosed: asthma, chronic heart failure, chronic obstructive pulmonary disease (COPD), coronary heart disease (CHD), depression, diabetes mellitus type 1 or 2, and rheumatoid arthritis (RA). Exact matching was used to account for differences in the distribution of age and sex between the case and matched control cohorts. Multi-morbidity was considered in sensitivity analyses by analyzing patients with only one UC. RESULTS: Patients with asthma, CHD, COPD, depression, and RA had, on average, a 30% increased risk of developing acute HZ compared to patients without any UC. RA was found to have the highest odds ratio among these conditions, varying from 1.37 to 1.57 for all age groups. Patients with depression also showed a high risk of developing HZ. Analysis of recurrence indicated that patients with at least one UC in the age groups 18-49 years and 50-59 years had the highest risk for a recurrent HZ. After experiencing a first recurrence, patients, regardless of age group, had a two- to threefold higher risk for a second recurrence. CONCLUSION: This study of representative claims data shows a higher HZ incidence and recurrence frequency in patients with UCs. These results provide relevant information for national health care guidelines and disease management programs.
INTRODUCTION: Several chronic underlying conditions (UCs) are known to be risk factors for developing herpes zoster (HZ) and to increase the severity of HZ and its risk of recurrence. The aim of this study was to investigate the incidence and recurrence of HZ in adult patients with one or multiple UCs. METHODS: A retrospective cohort study based on claims data representing 13% of the statutory health insurance population from 2007 to 2018 in Germany was performed. Patients aged ≥ 18 years were included when at least one of the following UCs was diagnosed: asthma, chronic heart failure, chronic obstructive pulmonary disease (COPD), coronary heart disease (CHD), depression, diabetes mellitus type 1 or 2, and rheumatoid arthritis (RA). Exact matching was used to account for differences in the distribution of age and sex between the case and matched control cohorts. Multi-morbidity was considered in sensitivity analyses by analyzing patients with only one UC. RESULTS:Patients with asthma, CHD, COPD, depression, and RA had, on average, a 30% increased risk of developing acute HZ compared to patients without any UC. RA was found to have the highest odds ratio among these conditions, varying from 1.37 to 1.57 for all age groups. Patients with depression also showed a high risk of developing HZ. Analysis of recurrence indicated that patients with at least one UC in the age groups 18-49 years and 50-59 years had the highest risk for a recurrent HZ. After experiencing a first recurrence, patients, regardless of age group, had a two- to threefold higher risk for a second recurrence. CONCLUSION: This study of representative claims data shows a higher HZ incidence and recurrence frequency in patients with UCs. These results provide relevant information for national health care guidelines and disease management programs.
Authors: Jennifer Katz; Edith M Cooper; Robert R Walther; Eugene W Sweeney; Robert H Dworkin Journal: Clin Infect Dis Date: 2004-07-19 Impact factor: 9.079
Authors: R N Werner; A F Nikkels; B Marinović; M Schäfer; M Czarnecka-Operacz; A M Agius; Z Bata-Csörgő; J Breuer; G Girolomoni; G E Gross; S Langan; R Lapid-Gortzak; T H Lesser; U Pleyer; J Sellner; G M Verjans; P Wutzler; C Dressler; R Erdmann; S Rosumeck; A Nast Journal: J Eur Acad Dermatol Venereol Date: 2016-11-02 Impact factor: 6.166
Authors: Bernhard Ultsch; Ingrid Köster; Thomas Reinhold; Anette Siedler; Gérard Krause; Andrea Icks; Ingrid Schubert; Ole Wichmann Journal: Eur J Health Econ Date: 2012-12-28
Authors: R N Werner; A F Nikkels; B Marinović; M Schäfer; M Czarnecka-Operacz; A M Agius; Z Bata-Csörgő; J Breuer; G Girolomoni; G E Gross; S Langan; R Lapid-Gortzak; T H Lesser; U Pleyer; J Sellner; G M Verjans; P Wutzler; C Dressler; R Erdmann; S Rosumeck; A Nast Journal: J Eur Acad Dermatol Venereol Date: 2016-11-02 Impact factor: 6.166