Literature DB >> 33954938

Global Lipidomics Profiling by a High Resolution LC-MS Platform.

Thomas Züllig1, Martin Trötzmüller1, Harald C Köfeler2.   

Abstract

Lipidomics is the determination of big lipid assemblies by mass spectrometry. When using chromatography coupled high resolution mass spectrometry, lipids can be identified by exact mass, fragment spectra, and retention time. This protocol covers lipid extraction, LC-MS data acquisition by Orbitrap mass spectrometry and data processing by Lipid Data Analyzer, a custom developed open source software.

Entities:  

Keywords:  Chromatography; LC-MS; Lipid data analyzer; Lipidomics; Lipids; Mass spectrometry

Year:  2021        PMID： 33954938     DOI： 10.1007/978-1-0716-1410-5_3

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  7 in total

Review 1.  Global analyses of cellular lipidomes directly from crude extracts of biological samples by ESI mass spectrometry: a bridge to lipidomics.

Authors:  Xianlin Han; Richard W Gross
Journal:  J Lipid Res       Date:  2003-04-01       Impact factor: 5.922

2.  Quantitative analysis of biological membrane lipids at the low picomole level by nano-electrospray ionization tandem mass spectrometry.

Authors:  B Brügger; G Erben; R Sandhoff; F T Wieland; W D Lehmann
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-18       Impact factor: 11.205

3.  Nontargeted quantitation of lipid classes using hydrophilic interaction liquid chromatography-electrospray ionization mass spectrometry with single internal standard and response factor approach.

Authors:  Eva Cífková; Michal Holčapek; Miroslav Lísa; Magdaléna Ovčačíková; Antonín Lyčka; Frédéric Lynen; Pat Sandra
Journal:  Anal Chem       Date:  2012-11-01       Impact factor: 6.986

4.  Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids.

Authors:  X Han; R W Gross
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-25       Impact factor: 11.205

5.  High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry.

Authors:  Max Scherer; Gerd Schmitz; Gerhard Liebisch
Journal:  Clin Chem       Date:  2009-03-26       Impact factor: 8.327

6.  Lipidomics by ultrahigh performance liquid chromatography-high resolution mass spectrometry and its application to complex biological samples.

Authors:  Alexander Triebl; Martin Trötzmüller; Jürgen Hartler; Tatjana Stojakovic; Harald C Köfeler
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2017-03-24       Impact factor: 3.205

7.  Deciphering lipid structures based on platform-independent decision rules.

Authors:  Jürgen Hartler; Alexander Triebl; Andreas Ziegl; Martin Trötzmüller; Gerald N Rechberger; Oana A Zeleznik; Kathrin A Zierler; Federico Torta; Amaury Cazenave-Gassiot; Markus R Wenk; Alexander Fauland; Craig E Wheelock; Aaron M Armando; Oswald Quehenberger; Qifeng Zhang; Michael J O Wakelam; Guenter Haemmerle; Friedrich Spener; Harald C Köfeler; Gerhard G Thallinger
Journal:  Nat Methods       Date:  2017-10-23       Impact factor: 28.547
  7 in total

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