Literature DB >> 33953524

Causal Estimation with Functional Confounders.

Aahlad Puli1, Adler J Perotte2, Rajesh Ranganath1,3.   

Abstract

Causal inference relies on two fundamental assumptions: ignorability and positivity. We study causal inference when the true confounder value can be expressed as a function of the observed data; we call this setting estimation with functional confounders (EFC). In this setting ignorability is satisfied, however positivity is violated, and causal inference is impossible in general. We consider two scenarios where causal effects are estimable. First, we discuss interventions on a part of the treatment called functional interventions and a sufficient condition for effect estimation of these interventions called functional positivity. Second, we develop conditions for nonparametric effect estimation based on the gradient fields of the functional confounder and the true outcome function. To estimate effects under these conditions, we develop Level-set Orthogonal Descent Estimation (LODE). Further, we prove error bounds on LODE's effect estimates, evaluate our methods on simulated and real data, and empirically demonstrate the value of EFC.

Entities:  

Year:  2020        PMID: 33953524      PMCID: PMC8096536     

Source DB:  PubMed          Journal:  Adv Neural Inf Process Syst        ISSN: 1049-5258


  13 in total

1.  Principal components analysis corrects for stratification in genome-wide association studies.

Authors:  Alkes L Price; Nick J Patterson; Robert M Plenge; Michael E Weinblatt; Nancy A Shadick; David Reich
Journal:  Nat Genet       Date:  2006-07-23       Impact factor: 38.330

2.  Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

Authors:  Lucia A Hindorff; Praveen Sethupathy; Heather A Junkins; Erin M Ramos; Jayashri P Mehta; Francis S Collins; Teri A Manolio
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-27       Impact factor: 11.205

3.  FaST linear mixed models for genome-wide association studies.

Authors:  Christoph Lippert; Jennifer Listgarten; Ying Liu; Carl M Kadie; Robert I Davidson; David Heckerman
Journal:  Nat Methods       Date:  2011-09-04       Impact factor: 28.547

Review 4.  Coeliac disease: dissecting a complex inflammatory disorder.

Authors:  Ludvig M Sollid
Journal:  Nat Rev Immunol       Date:  2002-09       Impact factor: 53.106

5.  Multiple common variants for celiac disease influencing immune gene expression.

Authors:  Patrick C A Dubois; Gosia Trynka; Lude Franke; Karen A Hunt; Jihane Romanos; Alessandra Curtotti; Alexandra Zhernakova; Graham A R Heap; Róza Adány; Arpo Aromaa; Maria Teresa Bardella; Leonard H van den Berg; Nicholas A Bockett; Emilio G de la Concha; Bárbara Dema; Rudolf S N Fehrmann; Miguel Fernández-Arquero; Szilvia Fiatal; Elvira Grandone; Peter M Green; Harry J M Groen; Rhian Gwilliam; Roderick H J Houwen; Sarah E Hunt; Katri Kaukinen; Dermot Kelleher; Ilma Korponay-Szabo; Kalle Kurppa; Padraic MacMathuna; Markku Mäki; Maria Cristina Mazzilli; Owen T McCann; M Luisa Mearin; Charles A Mein; Muddassar M Mirza; Vanisha Mistry; Barbara Mora; Katherine I Morley; Chris J Mulder; Joseph A Murray; Concepción Núñez; Elvira Oosterom; Roel A Ophoff; Isabel Polanco; Leena Peltonen; Mathieu Platteel; Anna Rybak; Veikko Salomaa; Joachim J Schweizer; Maria Pia Sperandeo; Greetje J Tack; Graham Turner; Jan H Veldink; Wieke H M Verbeek; Rinse K Weersma; Victorien M Wolters; Elena Urcelay; Bozena Cukrowska; Luigi Greco; Susan L Neuhausen; Ross McManus; Donatella Barisani; Panos Deloukas; Jeffrey C Barrett; Paivi Saavalainen; Cisca Wijmenga; David A van Heel
Journal:  Nat Genet       Date:  2010-02-28       Impact factor: 38.330

6.  Association study of IL2/IL21 and FcgRIIa: significant association with the IL2/IL21 region in Scandinavian coeliac disease families.

Authors:  S Adamovic; S S Amundsen; B A Lie; A H Gudjónsdóttir; H Ascher; J Ek; D A van Heel; S Nilsson; L M Sollid; A Torinsson Naluai
Journal:  Genes Immun       Date:  2008-04-17       Impact factor: 2.676

Review 7.  10 Years of GWAS Discovery: Biology, Function, and Translation.

Authors:  Peter M Visscher; Naomi R Wray; Qian Zhang; Pamela Sklar; Mark I McCarthy; Matthew A Brown; Jian Yang
Journal:  Am J Hum Genet       Date:  2017-07-06       Impact factor: 11.025

8.  Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Authors:  Carl A Anderson; Gabrielle Boucher; Charlie W Lees; Andre Franke; Mauro D'Amato; Kent D Taylor; James C Lee; Philippe Goyette; Marcin Imielinski; Anna Latiano; Caroline Lagacé; Regan Scott; Leila Amininejad; Suzannah Bumpstead; Leonard Baidoo; Robert N Baldassano; Murray Barclay; Theodore M Bayless; Stephan Brand; Carsten Büning; Jean-Frédéric Colombel; Lee A Denson; Martine De Vos; Marla Dubinsky; Cathryn Edwards; David Ellinghaus; Rudolf S N Fehrmann; James A B Floyd; Timothy Florin; Denis Franchimont; Lude Franke; Michel Georges; Jürgen Glas; Nicole L Glazer; Stephen L Guthery; Talin Haritunians; Nicholas K Hayward; Jean-Pierre Hugot; Gilles Jobin; Debby Laukens; Ian Lawrance; Marc Lémann; Arie Levine; Cecile Libioulle; Edouard Louis; Dermot P McGovern; Monica Milla; Grant W Montgomery; Katherine I Morley; Craig Mowat; Aylwin Ng; William Newman; Roel A Ophoff; Laura Papi; Orazio Palmieri; Laurent Peyrin-Biroulet; Julián Panés; Anne Phillips; Natalie J Prescott; Deborah D Proctor; Rebecca Roberts; Richard Russell; Paul Rutgeerts; Jeremy Sanderson; Miquel Sans; Philip Schumm; Frank Seibold; Yashoda Sharma; Lisa A Simms; Mark Seielstad; A Hillary Steinhart; Stephan R Targan; Leonard H van den Berg; Morten Vatn; Hein Verspaget; Thomas Walters; Cisca Wijmenga; David C Wilson; Harm-Jan Westra; Ramnik J Xavier; Zhen Z Zhao; Cyriel Y Ponsioen; Vibeke Andersen; Leif Torkvist; Maria Gazouli; Nicholas P Anagnou; Tom H Karlsen; Limas Kupcinskas; Jurgita Sventoraityte; John C Mansfield; Subra Kugathasan; Mark S Silverberg; Jonas Halfvarson; Jerome I Rotter; Christopher G Mathew; Anne M Griffiths; Richard Gearry; Tariq Ahmad; Steven R Brant; Mathias Chamaillard; Jack Satsangi; Judy H Cho; Stefan Schreiber; Mark J Daly; Jeffrey C Barrett; Miles Parkes; Vito Annese; Hakon Hakonarson; Graham Radford-Smith; Richard H Duerr; Séverine Vermeire; Rinse K Weersma; John D Rioux
Journal:  Nat Genet       Date:  2011-02-06       Impact factor: 38.330

9.  Second-generation PLINK: rising to the challenge of larger and richer datasets.

Authors:  Christopher C Chang; Carson C Chow; Laurent Cam Tellier; Shashaank Vattikuti; Shaun M Purcell; James J Lee
Journal:  Gigascience       Date:  2015-02-25       Impact factor: 6.524

10.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Authors: 
Journal:  Nature       Date:  2007-06-07       Impact factor: 49.962

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