Literature DB >> 3395329

Effect of GPIIb-IIIa complex ligands on calcium ion movement and cytoskeleton organization in activated platelets.

F Sinigaglia1, A Bisio, M Torti, C L Balduini, G Bertolino, C Balduini.   

Abstract

We studied the influence of the occupancy of the fibrinogen receptor (GP IIb-IIIa complex) on two early aspects of agonist induced platelet activation: the increase of the intracellular Ca2+ concentration and the cytoskeleton reorganization. A monoclonal antibody, a peptide containing the RGD sequence and fibrinogen purified from human plasma were used as GP IIb-IIIa ligands. The obtained results demonstrated that fibrinogen receptor occupancy inhibits Ca2+ movement and cytoskeleton reorganization caused by low thrombin concentration and ADP.

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Year:  1988        PMID： 3395329     DOI： 10.1016/0006-291x(88)90678-x

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Accumulation of PtdIns(3,4)P2 and PtdIns(3,4,5)P3 in thrombin-stimulated platelets. Different sensitivities to Ca2+ or functional integrin.

Authors:  A Sorisky; W G King; S E Rittenhouse
Journal:  Biochem J       Date:  1992-09-01       Impact factor: 3.857

2.  Ligands to the platelet fibrinogen receptor glycoprotein IIb-IIIa do not affect agonist-induced second messengers Ca2+ or cyclic AMP.

Authors:  J A Williams; B Ashby; J L Daniel
Journal:  Biochem J       Date:  1990-08-15       Impact factor: 3.857

3.  Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation.

Authors:  M Torti; G Ramaschi; F Sinigaglia; E G Lapetina; C Balduini
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-15       Impact factor: 11.205

4.  Glycoprotein IIb-IIIa and the translocation of Rap2B to the platelet cytoskeleton.

Authors:  M Torti; G Ramaschi; F Sinigaglia; E G Lapetina; C Balduini
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

5.  Systemic lysis protects against the effects of platelet activation during coronary thrombolysis.

Authors:  D J Fitzgerald; M Hanson; G A FitzGerald
Journal:  J Clin Invest       Date:  1991-11       Impact factor: 14.808

6.  Group IVA cytosolic phospholipase A2 (cPLA2alpha) and integrin alphaIIbbeta3 reinforce each other's functions during alphaIIbbeta3 signaling in platelets.

Authors:  Nicolas Prévost; John V Mitsios; Hisashi Kato; John E Burke; Edward A Dennis; Takao Shimizu; Sanford J Shattil
Journal:  Blood       Date:  2008-10-07       Impact factor: 22.113
  6 in total

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