Literature DB >> 33952722

Emerging roles of nucleotide metabolism in cancer development: progress and prospect.

Jingsong Ma1,2, Mengya Zhong1,2, Yubo Xiong1,2, Zhi Gao3, Zhengxin Wu4, Yu Liu5, Xuehui Hong1,2.   

Abstract

Abnormal cancer metabolism occurs throughout the development of tumors. Recent studies have shown that abnormal nucleotide metabolism not only accelerates the development of tumors but also inhibits the normal immune response in the tumor microenvironment. Although few relevant experiments and reports are available, study of the interaction between nucleotide metabolism and cancer development is rapidly developing. The intervention, alteration or regulation of molecular mechanisms related to abnormal nucleotide metabolism in tumor cells has become a new idea and strategy for the treatment of tumors and prevention of recurrence and metastasis. Determining how nucleotide metabolism regulates the occurrence and progression of tumors still needs long-term and extensive research and exploration.

Entities:  

Keywords:  key metabolic enzyme; nucleotide metabolism; oncogene-induced senescence; signaling pathway; tumor immunity

Year:  2021        PMID: 33952722     DOI: 10.18632/aging.202962

Source DB:  PubMed          Journal:  Aging (Albany NY)        ISSN: 1945-4589            Impact factor:   5.682


  8 in total

Review 1.  Alterations in cellular metabolisms after Imatinib therapy: a review.

Authors:  Veerandra Kumar; Priyanka Singh; Sonu Kumar Gupta; Villayat Ali; Malkhey Verma
Journal:  Med Oncol       Date:  2022-05-16       Impact factor: 3.064

Review 2.  Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy.

Authors:  Huai-Liang Wu; Yue Gong; Peng Ji; Yi-Fan Xie; Yi-Zhou Jiang; Guang-Yu Liu
Journal:  J Hematol Oncol       Date:  2022-04-27       Impact factor: 23.168

3.  Identification of crucial genes of pyrimidine metabolism as biomarkers for gastric cancer prognosis.

Authors:  Zhengxin Wu; Jinshui Tan; Yifan Zhuang; Mengya Zhong; Yubo Xiong; Jingsong Ma; Yan Yang; Zhi Gao; Jiabao Zhao; Zhijian Ye; Huiwen Zhou; Yuekun Zhu; Haijie Lu; Xuehui Hong
Journal:  Cancer Cell Int       Date:  2021-12-14       Impact factor: 5.722

4.  Pre- and Post-Resection Urine Metabolic Profiles of Bladder Cancer Patients: Results of Preliminary Studies on Time Series Metabolomics Analysis.

Authors:  Julia Jacyna; Marta Kordalewska; Małgorzata Artymowicz; Marcin Markuszewski; Marcin Matuszewski; Michał J Markuszewski
Journal:  Cancers (Basel)       Date:  2022-02-25       Impact factor: 6.639

Review 5.  The Employment of Genera Vaccinium, Citrus, Olea, and Cynara Polyphenols for the Reduction of Selected Anti-Cancer Drug Side Effects.

Authors:  Jessica Maiuolo; Vincenzo Musolino; Micaela Gliozzi; Cristina Carresi; Francesca Oppedisano; Saverio Nucera; Federica Scarano; Miriam Scicchitano; Lorenza Guarnieri; Francesca Bosco; Roberta Macrì; Stefano Ruga; Antonio Cardamone; Anna Rita Coppoletta; Sara Ilari; Annachiara Mollace; Carolina Muscoli; Francesco Cognetti; Vincenzo Mollace
Journal:  Nutrients       Date:  2022-04-10       Impact factor: 6.706

6.  Identify metabolism-related genes IDO1, ALDH2, NCOA2, SLC7A5, SLC3A2, LDHB, and HPRT1 as potential prognostic markers and correlate with immune infiltrates in head and neck squamous cell carcinoma.

Authors:  Ce Li; Shuai Chen; Wenming Jia; Wenming Li; Dongmin Wei; Shengda Cao; Ye Qian; Rui Guan; Heng Liu; Dapeng Lei
Journal:  Front Immunol       Date:  2022-08-25       Impact factor: 8.786

7.  Targeting E2F Sensitizes Prostate Cancer Cells to Drug-Induced Replication Stress by Promoting Unscheduled CDK1 Activity.

Authors:  Mohaddase Hamidi; Ainhoa Eriz; Jone Mitxelena; Larraitz Fernandez-Ares; Igor Aurrekoetxea; Patricia Aspichueta; Ainhoa Iglesias-Ara; Ana M Zubiaga
Journal:  Cancers (Basel)       Date:  2022-10-10       Impact factor: 6.575

8.  The downregulated drug-metabolism related ALDH6A1 serves as predictor for prognosis and therapeutic immune response in gastric cancer.

Authors:  Yuan Cai; Rong Zeng; Jinwu Peng; Wei Liu; Qingchun He; Zhijie Xu; Ning Bai
Journal:  Aging (Albany NY)       Date:  2022-09-12       Impact factor: 5.955

  8 in total

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