Altuğ Ösken1, Ahmet Öz1,2, Muhammed Keskin1,3, Evliya Akdeniz1,4, Hasan Şahan5, Seviye Bora Şişman5, Neşe Çam1, Sinan Şahin5. 1. Department of Cardiology, Siyami Ersek Thoracic and Cardiovascular Surgery Centre, Training and Research Hospital, Istanbul, Turkey. 2. Department of Cardiology, Istanbul Training and Research Hospital, Istanbul, Turkey. 3. Department of Cardiology, Sultan 2. Abdulhamid Han Training and Research Hospital, Istanbul, Turkey. 4. Department of Cardiology, Başkent University, Faculty of Medicine, Istanbul, Turkey. 5. Department of Radiology, Siyami Ersek Thoracic and Cardiovascular Surgery Centre, Training and Research Hospital, Istanbul, Turkey.
Abstract
OBJECTIVES: Contrast-induced acute kidney injury (CI-AKI) is a life-threatening complication that leads to comorbidities and prolonged hospital stay lengths in the setting of peripheral interventions. The presence of some CI-AKI risk factors has already been investigated. In this study, we evaluated the predictors of CI-AKI after carotid artery stenting. METHODS: A total of 389 patients with 50% to 99% carotid artery stenosis who underwent carotid artery stenting were included in this study. Patients were grouped according to CI-AKI status. RESULTS: CI-AKI developed in 26 (6.6%) patients. Age, baseline creatinine level, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were higher and estimated glomerular filtration rate, haemoglobin and lymphocyte count were lower in CI-AKI patients. In the multivariate regression analysis, the neutrophil-to-lymphocyte ratio triggered a 1.39- to 2.63-fold increase in the risk of CI-AKI onset (p < 0.001). CONCLUSIONS: The neutrophil-to-lymphocyte ratio may be a significant predictor of CI-AKI in patients with carotid artery stenting and higher neutrophil-to-lymphocyte ratio values may be independently associated with CI-AKI.
OBJECTIVES: Contrast-induced acute kidney injury (CI-AKI) is a life-threatening complication that leads to comorbidities and prolonged hospital stay lengths in the setting of peripheral interventions. The presence of some CI-AKI risk factors has already been investigated. In this study, we evaluated the predictors of CI-AKI after carotid artery stenting. METHODS: A total of 389 patients with 50% to 99% carotid artery stenosis who underwent carotid artery stenting were included in this study. Patients were grouped according to CI-AKI status. RESULTS: CI-AKI developed in 26 (6.6%) patients. Age, baseline creatinine level, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio were higher and estimated glomerular filtration rate, haemoglobin and lymphocyte count were lower in CI-AKI patients. In the multivariate regression analysis, the neutrophil-to-lymphocyte ratio triggered a 1.39- to 2.63-fold increase in the risk of CI-AKI onset (p < 0.001). CONCLUSIONS: The neutrophil-to-lymphocyte ratio may be a significant predictor of CI-AKI in patients with carotid artery stenting and higher neutrophil-to-lymphocyte ratio values may be independently associated with CI-AKI.
Entities:
Keywords:
Carotid artery stenting; contrast-induced acute kidney injury; neutrophil-to-lymphocyte ratio
Authors: Rajesh Kumar; Kamran Ahmed Khan; Lajpat Rai; Bashir Ahmed Solangi; Ali Ammar; Muhammad Nauman Khan; Ifikhar Ahmed; Bilal Ahmed; Tahir Saghir; Jawaid Akbar Sial; Musa Karim Journal: Int J Cardiol Heart Vasc Date: 2021-10-29