Literature DB >> 33951562

Is Human Walking a Network Medicine Problem? An Analysis Using Symbolic Regression Models with Genetic Programming.

Pritika Dasgupta1, James Alexander Hughes2, Mark Daley3, Ervin Sejdić4.   

Abstract

BACKGROUND AND
OBJECTIVE: Human walking is typically assessed using a sensor placed on the lower back or the hip. Such analyses often ignore that the arms, legs, and body trunk movements all have significant roles during walking; in other words, these body nodes with accelerometers form a body sensor network (BSN). BSN refers to a network of wearable sensors or devices on the human body that collects physiological signals. Our study proposes that human locomotion could be considered as a network of well-connected nodes.
METHODS: While hypothesizing that accelerometer data can model this BSN, we collected accelerometer signals from six body areas from ten healthy participants performing a cognitive task. Machine learning based on genetic programming was used to produce a collection of non-linear symbolic models of human locomotion.
RESULTS: With implications in precision medicine, our primary finding was that our BSN models fit the data from the lower back's accelerometer and describe subject-specific data the best compared to all other models. Across subjects, models were less effective due to the diversity of human sizes.
CONCLUSIONS: A BSN relationship between all six body nodes has been shown to describe the subject-specific data, which indicates that the network-medicine relationship between these nodes is essential in adequately describing human walking. Our gait analyses can be used for several clinical applications such as medical diagnostics as well as creating a baseline for healthy walking with and without a cognitive load.
Copyright © 2021. Published by Elsevier B.V.

Entities:  

Keywords:  acceleration gait measures; genetic programming; mathematical model; symbolic regression; walking; wearables

Mesh:

Year:  2021        PMID: 33951562      PMCID: PMC8205964          DOI: 10.1016/j.cmpb.2021.106104

Source DB:  PubMed          Journal:  Comput Methods Programs Biomed        ISSN: 0169-2607            Impact factor:   7.027


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