Computational Methods for the Elucidation of Protein Structure and Interactions.

Biologists are increasingly aware of the importance of protein structure in revealing function. The computational tools now exist which allow researchers to model unknown proteins simply on the basis of their primary sequence. However, for the non-specialist bioinformatician, there is a dazzling array of terminology, acronyms, and competing computer software available for this process. This review is intended to highlight the key stages of computational protein structure prediction, as well as explain the reasons behind some of the procedures and list some established workarounds for common pitfalls. Thereafter follows a review of five one-stop servers for start-to-finish structure prediction.