The roles of the lateral intraparietal area and frontal eye field in guiding eye movements in free viewing search behavior.

The lateral intraparietal area (LIP) and frontal eye field (FEF) have been shown to play significant roles in oculomotor control, yet most studies have found that the two areas behave similarly. To identify the unique roles each area plays in guiding eye movements, we recorded 200 LIP neurons and 231 FEF neurons from four animals performing a free viewing visual foraging task. We analyzed how neuronal responses were modulated by stimulus identity and the animals' choice of where to make a saccade. We additionally analyzed the comodulation of the sensory signals and the choice signal to identify how the sensory signals drove the choice. We found a clearly defined division of labor: LIP provided a stable map integrating task rules and stimulus identity, whereas FEF responses were dynamic, representing more complex information and, just before the saccade, were integrated with task rules and stimulus identity to decide where to move the eye.NEW & NOTEWORTHY The lateral intrapareital area (LIP) and frontal eye field (FEF) are known to contribute to guiding eye movements, but little is known about the unique roles that each area plays. Using a free viewing visual search task, we found that LIP provides a stable map of the visual world, integrating task rules and stimulus identity. FEF activity is consistently modulated by more complex information but, just before the saccade, integrates all the information to make the final decision about where to move.