Eng Hooi Tan1, Andrea Li Ann Wong2, Chuan Chien Tan3, Patrick Wong4, Sing Huang Tan5, Li En Yvonne Ang2, Siew Eng Lim2, Wan Qin Chong2, Jingshan Ho2, Soo Chin Lee2, Bee Choo Tai6,7. 1. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, #10-03F, Singapore, 117549, Singapore. 2. Department of Haematology-Oncology, National University Cancer Institute, NUHS, Tower Block Level 7, 1E Kent Ridge Road, Singapore, 119228, Singapore. 3. Department of General Surgery, Ng Teng Fong General Hospital, 1 Jurong East Street 21, Singapore, 609606, Singapore. 4. Division of Oncology Pharmacy, National University Cancer Institute, NUHS, Tower Block Level 7, 1E Kent Ridge Road, Singapore, 119228, Singapore. 5. OncoCare Cancer Centre, 6 Napier Road, #02-17/18/19, Gleneagles Medical Centre, Singapore, 258499, Singapore. 6. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 12 Science Drive 2, #10-03F, Singapore, 117549, Singapore. ephtbc@nus.edu.sg. 7. Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 1E Kent Ridge Road, Singapore, 119228, Singapore. ephtbc@nus.edu.sg.
Abstract
PURPOSE: To identify a structure to explain the relationship between socio-clinico factors, necessity-concerns beliefs, and perceived barriers to adherence with adjuvant endocrine therapy (AET) amongst women with breast cancer. METHODS: Participants were 244 patients with early-stage breast cancer recruited from two tertiary hospitals from May 2015 to December 2018 who completed questionnaires on medication adherence (Simplified Medication Adherence Questionnaire), necessity-concerns beliefs (Beliefs about Medicine Questionnaire), and barriers to adherence (Adherence Starts with Knowledge Questionnaire). Socio-clinico variables were collected via interview and medical records review. Structural equation modelling was applied to examine the relationships between these variables and possible mediating effects of necessity-concerns beliefs on adherence to AET. RESULTS: The median age of the study participants was 61 (range 32-80) years and the median duration on AET was 1.6 (IQR 1.2-2.6) years. Adherence was positively associated with age (β = 0.145, 95% CI: 0.011 to 0.279, p = 0.034) and negatively associated with barriers (β = - 0.381, 95% CI: - 0.511 to - 0.251, p < 0.001). There was no effect of Necessity (β = 0.006, 95% CI: - 0.145 to 0.158, p = 0.933) or Concerns (β = 0.041, 95% CI: - 0.117 to 0.199, p = 0.614) on adherence. Necessity-concerns beliefs were also not significant mediators in the relationship between socio-clinico factors and medication adherence. CONCLUSIONS: Older age and lower barriers to adherence were associated with higher adherence scores. Necessity-concerns beliefs did not have a significant effect on adherence as majority of the patients identified forgetfulness as a reason for non-adherence.
PURPOSE: To identify a structure to explain the relationship between socio-clinico factors, necessity-concerns beliefs, and perceived barriers to adherence with adjuvant endocrine therapy (AET) amongst women with breast cancer. METHODS:Participants were 244 patients with early-stage breast cancer recruited from two tertiary hospitals from May 2015 to December 2018 who completed questionnaires on medication adherence (Simplified Medication Adherence Questionnaire), necessity-concerns beliefs (Beliefs about Medicine Questionnaire), and barriers to adherence (Adherence Starts with Knowledge Questionnaire). Socio-clinico variables were collected via interview and medical records review. Structural equation modelling was applied to examine the relationships between these variables and possible mediating effects of necessity-concerns beliefs on adherence to AET. RESULTS: The median age of the study participants was 61 (range 32-80) years and the median duration on AET was 1.6 (IQR 1.2-2.6) years. Adherence was positively associated with age (β = 0.145, 95% CI: 0.011 to 0.279, p = 0.034) and negatively associated with barriers (β = - 0.381, 95% CI: - 0.511 to - 0.251, p < 0.001). There was no effect of Necessity (β = 0.006, 95% CI: - 0.145 to 0.158, p = 0.933) or Concerns (β = 0.041, 95% CI: - 0.117 to 0.199, p = 0.614) on adherence. Necessity-concerns beliefs were also not significant mediators in the relationship between socio-clinico factors and medication adherence. CONCLUSIONS: Older age and lower barriers to adherence were associated with higher adherence scores. Necessity-concerns beliefs did not have a significant effect on adherence as majority of the patients identified forgetfulness as a reason for non-adherence.
Authors: F J Ortega Suárez; J Sánchez Plumed; M A Pérez Valentín; P Pereira Palomo; M A Muñoz Cepeda; D Lorenzo Aguiar Journal: Nefrologia Date: 2011 Impact factor: 2.033
Authors: Eng Hooi Tan; Andrea Li Ann Wong; Chuan Chien Tan; Patrick Wong; Sing Huang Tan; Li En Yvonne Ang; Siew Eng Lim; Wan Qin Chong; Jingshan Ho; Soo Chin Lee; Bee Choo Tai Journal: J Health Psychol Date: 2021-02-07
Authors: Sophie M C Green; David P French; Christopher D Graham; Louise H Hall; Nikki Rousseau; Robbie Foy; Jane Clark; Catherine Parbutt; Erin Raine; Benjamin Gardner; Galina Velikova; Sally J L Moore; Jacqueline Buxton; Samuel G Smith Journal: BMC Health Serv Res Date: 2022-08-24 Impact factor: 2.908