Literature DB >> 33948723

Recurrent Wnt medulloblastoma treated with marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue: a dual case report and review of the literature.

Micah K Harris1,2, Margaret Shatara1,3, Zachary Funk1, Joseph Stanek1, Daniel R Boué4, Jeremy Jones5, Jonathan L Finlay1, Mohamed S Abdelbaki6,7.   

Abstract

Wnt-activated medulloblastoma (MB) confers an excellent prognosis. However, specific treatment strategies for patients with relapsed Wnt-MB are unknown. We report two patients with recurrent beta-catenin nucleopositive Wnt-MB successfully treated by incorporating marrow-ablative chemotherapy and autologous hematopoietic progenitor cell rescue (HDCx/AuHPCR). We also present a review of the literature for previously reported cases of relapsed Wnt-MB. We propose that patients with recurrent Wnt-MB may be treated using a multi-disciplinary approach that includes HDCx/AuHPCR with or without re-irradiation.
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

Entities:  

Keywords:  CTNNB1; Case report; Marrow-ablative chemotherapy; Medulloblastoma; Recurrent; Wnt

Mesh：

Year:  2021        PMID： 33948723     DOI： 10.1007/s00381-021-05197-6

Source DB:  PubMed          Journal:  Childs Nerv Syst        ISSN： 0256-7040            Impact factor:   1.475


  16 in total

Review 1.  Medulloblastoma.

Authors:  Paul A Northcott; Giles W Robinson; Christian P Kratz; Donald J Mabbott; Scott L Pomeroy; Steven C Clifford; Stefan Rutkowski; David W Ellison; David Malkin; Michael D Taylor; Amar Gajjar; Stefan M Pfister
Journal:  Nat Rev Dis Primers       Date:  2019-02-14       Impact factor: 52.329

2.  Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial.

Authors:  Amar Gajjar; Murali Chintagumpala; David Ashley; Stewart Kellie; Larry E Kun; Thomas E Merchant; Shaio Woo; Greg Wheeler; Valerie Ahern; Matthew J Krasin; Maryam Fouladi; Alberto Broniscer; Robert Krance; Gregory A Hale; Clinton F Stewart; Robert Dauser; Robert A Sanford; Christine Fuller; Ching Lau; James M Boyett; Dana Wallace; Richard J Gilbertson
Journal:  Lancet Oncol       Date:  2006-10       Impact factor: 41.316

3.  Survival Following Tumor Recurrence in Children With Medulloblastoma.

Authors:  Donna L Johnston; Daniel Keene; Douglas Strother; Maria Taneva; Lucie Lafay-Cousin; Chris Fryer; Katrin Scheinemann; Anne-Sophie Carret; Adam Fleming; Samina Afzal; Beverly Wilson; Lynette Bowes; Shayna Zelcer; Chris Mpofu; Mariana Silva; Valerie Larouche; Josee Brossard; Eric Bouffet
Journal:  J Pediatr Hematol Oncol       Date:  2018-04       Impact factor: 1.289

4.  Medulloblastoma: Distinctive Histo-Molecular Correlation with Clinical Profile, Radiologic Characteristics, and Surgical Outcome.

Authors:  Vinayak Narayan; Harsha Sugur; Janhvi Jaiswal; H R Arvinda; Arimappamagan Arivazhagan; Sampath Somanna; Vani Santosh
Journal:  Pediatr Neurosurg       Date:  2019-09-03       Impact factor: 1.162

5.  Intertumoral Heterogeneity within Medulloblastoma Subgroups.

Authors:  Florence M G Cavalli; Marc Remke; Ladislav Rampasek; John Peacock; David J H Shih; Betty Luu; Livia Garzia; Jonathon Torchia; Carolina Nor; A Sorana Morrissy; Sameer Agnihotri; Yuan Yao Thompson; Claudia M Kuzan-Fischer; Hamza Farooq; Keren Isaev; Craig Daniels; Byung-Kyu Cho; Seung-Ki Kim; Kyu-Chang Wang; Ji Yeoun Lee; Wieslawa A Grajkowska; Marta Perek-Polnik; Alexandre Vasiljevic; Cecile Faure-Conter; Anne Jouvet; Caterina Giannini; Amulya A Nageswara Rao; Kay Ka Wai Li; Ho-Keung Ng; Charles G Eberhart; Ian F Pollack; Ronald L Hamilton; G Yancey Gillespie; James M Olson; Sarah Leary; William A Weiss; Boleslaw Lach; Lola B Chambless; Reid C Thompson; Michael K Cooper; Rajeev Vibhakar; Peter Hauser; Marie-Lise C van Veelen; Johan M Kros; Pim J French; Young Shin Ra; Toshihiro Kumabe; Enrique López-Aguilar; Karel Zitterbart; Jaroslav Sterba; Gaetano Finocchiaro; Maura Massimino; Erwin G Van Meir; Satoru Osuka; Tomoko Shofuda; Almos Klekner; Massimo Zollo; Jeffrey R Leonard; Joshua B Rubin; Nada Jabado; Steffen Albrecht; Jaume Mora; Timothy E Van Meter; Shin Jung; Andrew S Moore; Andrew R Hallahan; Jennifer A Chan; Daniela P C Tirapelli; Carlos G Carlotti; Maryam Fouladi; José Pimentel; Claudia C Faria; Ali G Saad; Luca Massimi; Linda M Liau; Helen Wheeler; Hideo Nakamura; Samer K Elbabaa; Mario Perezpeña-Diazconti; Fernando Chico Ponce de León; Shenandoah Robinson; Michal Zapotocky; Alvaro Lassaletta; Annie Huang; Cynthia E Hawkins; Uri Tabori; Eric Bouffet; Ute Bartels; Peter B Dirks; James T Rutka; Gary D Bader; Jüri Reimand; Anna Goldenberg; Vijay Ramaswamy; Michael D Taylor
Journal:  Cancer Cell       Date:  2017-06-12       Impact factor: 31.743

6.  Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis.

Authors:  Stefan Rutkowski; Katja von Hoff; Angela Emser; Isabella Zwiener; Torsten Pietsch; Dominique Figarella-Branger; Felice Giangaspero; David W Ellison; Maria-Luisa Garre; Veronica Biassoni; Richard G Grundy; Jonathan L Finlay; Girish Dhall; Marie-Anne Raquin; Jacques Grill
Journal:  J Clin Oncol       Date:  2010-10-12       Impact factor: 44.544

7.  Treatment of early childhood medulloblastoma by postoperative chemotherapy alone.

Authors:  Stefan Rutkowski; Udo Bode; Frank Deinlein; Holger Ottensmeier; Monika Warmuth-Metz; Niels Soerensen; Norbert Graf; Angela Emser; Torsten Pietsch; Johannes E A Wolff; Rolf D Kortmann; Joachim Kuehl
Journal:  N Engl J Med       Date:  2005-03-10       Impact factor: 91.245

8.  DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas.

Authors:  Andrey Korshunov; Felix Sahm; Olga Zheludkova; Andrey Golanov; Damian Stichel; Daniel Schrimpf; Marina Ryzhova; Alexander Potapov; Antje Habel; Jochen Meyer; Peter Lichter; David T W Jones; Andreas von Deimling; Stefan M Pfister; Marcel Kool
Journal:  Neuro Oncol       Date:  2019-02-14       Impact factor: 12.300

9.  Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis.

Authors:  Vijay Ramaswamy; Marc Remke; Eric Bouffet; Claudia C Faria; Sebastien Perreault; Yoon-Jae Cho; David J Shih; Betty Luu; Adrian M Dubuc; Paul A Northcott; Ulrich Schüller; Sridharan Gururangan; Roger McLendon; Darell Bigner; Maryam Fouladi; Keith L Ligon; Scott L Pomeroy; Sandra Dunn; Joanna Triscott; Nada Jabado; Adam Fontebasso; David T W Jones; Marcel Kool; Matthias A Karajannis; Sharon L Gardner; David Zagzag; Sofia Nunes; José Pimentel; Jaume Mora; Eric Lipp; Andrew W Walter; Marina Ryzhova; Olga Zheludkova; Ella Kumirova; Jad Alshami; Sidney E Croul; James T Rutka; Cynthia Hawkins; Uri Tabori; Kari-Elise T Codispoti; Roger J Packer; Stefan M Pfister; Andrey Korshunov; Michael D Taylor
Journal:  Lancet Oncol       Date:  2013-10-17       Impact factor: 41.316

10.  Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.

Authors:  Sebastian M Waszak; Paul A Northcott; Ivo Buchhalter; Giles W Robinson; Christian Sutter; Susanne Groebner; Kerstin B Grund; Laurence Brugières; David T W Jones; Kristian W Pajtler; A Sorana Morrissy; Marcel Kool; Dominik Sturm; Lukas Chavez; Aurelie Ernst; Sebastian Brabetz; Michael Hain; Thomas Zichner; Maia Segura-Wang; Joachim Weischenfeldt; Tobias Rausch; Balca R Mardin; Xin Zhou; Cristina Baciu; Christian Lawerenz; Jennifer A Chan; Pascale Varlet; Lea Guerrini-Rousseau; Daniel W Fults; Wiesława Grajkowska; Peter Hauser; Nada Jabado; Young-Shin Ra; Karel Zitterbart; Suyash S Shringarpure; Francisco M De La Vega; Carlos D Bustamante; Ho-Keung Ng; Arie Perry; Tobey J MacDonald; Pablo Hernáiz Driever; Anne E Bendel; Daniel C Bowers; Geoffrey McCowage; Murali M Chintagumpala; Richard Cohn; Timothy Hassall; Gudrun Fleischhack; Tone Eggen; Finn Wesenberg; Maria Feychting; Birgitta Lannering; Joachim Schüz; Christoffer Johansen; Tina V Andersen; Martin Röösli; Claudia E Kuehni; Michael Grotzer; Kristina Kjaerheim; Camelia M Monoranu; Tenley C Archer; Elizabeth Duke; Scott L Pomeroy; Redmond Shelagh; Stephan Frank; David Sumerauer; Wolfram Scheurlen; Marina V Ryzhova; Till Milde; Christian P Kratz; David Samuel; Jinghui Zhang; David A Solomon; Marco Marra; Roland Eils; Claus R Bartram; Katja von Hoff; Stefan Rutkowski; Vijay Ramaswamy; Richard J Gilbertson; Andrey Korshunov; Michael D Taylor; Peter Lichter; David Malkin; Amar Gajjar; Jan O Korbel; Stefan M Pfister
Journal:  Lancet Oncol       Date:  2018-05-09       Impact factor: 54.433
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