Dandan Li1,2,3,4, Fengyan Zhang5, Lu Wang1, Yifan Zhang4, Tingting Yang4, Kai Wang6,7,8,9,10, Chunyan Zhu11,12,13. 1. Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. 2. Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, 230022, China. 3. Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, 230022, China. 4. School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, 230022, China. 5. Children's Rehabilitation Department, Wuhan Mental Health Center, Wuhan, 430012, China. 6. Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China. wangkai1964@126.com. 7. Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, 230022, China. wangkai1964@126.com. 8. Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, 230022, China. wangkai1964@126.com. 9. School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, 230022, China. wangkai1964@126.com. 10. Institute of Artificial Intelligence, Hefei Comprehensive National Science Center, Hefei, 230022, China. wangkai1964@126.com. 11. Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, 230022, China. ayswallow@126.com. 12. Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, 230022, China. ayswallow@126.com. 13. School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, 230022, China. ayswallow@126.com.
Abstract
OBJECTIVE: Numerous studies have identified impaired decision making (DM) under both ambiguity and risk in adult patients with schizophrenia. However, the assessment of DM in patients with adolescent-onset schizophrenia (AOS) has been challenging as a result of the instability and heterogeneity of manifestations. The Iowa Gambling Task (IGT) and Game of Dice Task (GDT), which are frequently used to evaluate DM respectively under ambiguity and risk, are sensitive to adolescents and neuropsychiatric patients. Our research intended to examine the performance of DM in a relatively large sample of patients with AOS using the above-mentioned two tasks. We also aimed to take a closer look at the relationship between DM and symptom severity of schizophrenia. METHODS: We compared the performance of DM in 71 patients with AOS and 53 well-matched healthy controls using IGT for DM under ambiguity and GDT for DM under risk through net scores, total scores and feedback ration. Neuropsychological tests were conducted in all participants. Clinical symptoms were evaluated by using Positive and Negative Syndrome Scale (PANSS) in 71 patients with AOS. Pearson's correlation revealed the relationship among total score of DM and clinical and neuropsychological data. RESULTS: Compared to healthy controls, patients with AOS failed to show learning effect and had a significant difference on the 5th block in IGT and conducted more disadvantageous choices as well as exhibited worse negative feedback rate in GDT. Apart from DM impairment under risk, diminished DM abilities under ambiguity were found related to poor executive function in AOS in the present study. CONCLUSIONS: Our findings unveiled the abnormal pattern of DM in AOS, mainly reflected under the risky condition, extending the knowledge on the performance of DM under ambiguity and risk in AOS. Inefficient DM under risk may account for the lagging impulse control and the combined effects of developmental disease. In addition, our study demonstrated that the performance on IGT was related to executive function in AOS.
OBJECTIVE: Numerous studies have identified impaired decision making (DM) under both ambiguity and risk in adult patients with schizophrenia. However, the assessment of DM in patients with adolescent-onset schizophrenia (AOS) has been challenging as a result of the instability and heterogeneity of manifestations. The Iowa Gambling Task (IGT) and Game of Dice Task (GDT), which are frequently used to evaluate DM respectively under ambiguity and risk, are sensitive to adolescents and neuropsychiatric patients. Our research intended to examine the performance of DM in a relatively large sample of patients with AOS using the above-mentioned two tasks. We also aimed to take a closer look at the relationship between DM and symptom severity of schizophrenia. METHODS: We compared the performance of DM in 71 patients with AOS and 53 well-matched healthy controls using IGT for DM under ambiguity and GDT for DM under risk through net scores, total scores and feedback ration. Neuropsychological tests were conducted in all participants. Clinical symptoms were evaluated by using Positive and Negative Syndrome Scale (PANSS) in 71 patients with AOS. Pearson's correlation revealed the relationship among total score of DM and clinical and neuropsychological data. RESULTS: Compared to healthy controls, patients with AOS failed to show learning effect and had a significant difference on the 5th block in IGT and conducted more disadvantageous choices as well as exhibited worse negative feedback rate in GDT. Apart from DM impairment under risk, diminished DM abilities under ambiguity were found related to poor executive function in AOS in the present study. CONCLUSIONS: Our findings unveiled the abnormal pattern of DM in AOS, mainly reflected under the risky condition, extending the knowledge on the performance of DM under ambiguity and risk in AOS. Inefficient DM under risk may account for the lagging impulse control and the combined effects of developmental disease. In addition, our study demonstrated that the performance on IGT was related to executive function in AOS.
Entities:
Keywords:
Adolescent-onset schizophrenia; Decision making; Game of dice task; Iowa gambling task
Authors: Anne Katrine Pagsberg; Simon Tarp; Dorte Glintborg; Anne Dorte Stenstrøm; Anders Fink-Jensen; Christoph Ulrich Correll; Robin Christensen Journal: J Am Acad Child Adolesc Psychiatry Date: 2016-12-29 Impact factor: 8.829