Literature DB >> 33946979

Role of Choline in Ocular Diseases.

Jin-Sun Hwang1, Young-Joo Shin1.   

Abstract

Choline is essential for maintaining the structure and function of cells in humans. Choline plays an important role in eye health and disease. It is a precursor of acetylcholine, a neurotransmitter of the parasympathetic nervous system, and it is involved in the production and secretion of tears by the lacrimal glands. It also contributes to the stability of the cells and tears on the ocular surface and is involved in retinal development and differentiation. Choline deficiency is associated with retinal hemorrhage, glaucoma, and dry eye syndrome. Choline supplementation may be effective for treating these diseases.

Entities:  

Keywords:  choline; diabetic retinopathy; dry eye syndrome; glaucoma; ocular disease; retina

Year:  2021        PMID: 33946979     DOI: 10.3390/ijms22094733

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN: 1422-0067            Impact factor:   5.923


  120 in total

1.  Effects of L-carnitine, erythritol and betaine on pro-inflammatory markers in primary human corneal epithelial cells exposed to hyperosmotic stress.

Authors:  Xia Hua; Zhitao Su; Ruzhi Deng; Jing Lin; De-Quan Li; Stephen C Pflugfelder
Journal:  Curr Eye Res       Date:  2014-10-01       Impact factor: 2.424

2.  Oxidation-induced changes in human lens epithelial cells. 1. Phospholipids.

Authors:  Li Huang; Rosendo Estrada; Marta C Yappert; Douglas Borchman
Journal:  Free Radic Biol Med       Date:  2006-08-04       Impact factor: 7.376

3.  Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation.

Authors:  Shanmugam Panneer Selvam; Ryan M De Palma; Joshua J Oaks; Natalia Oleinik; Yuri K Peterson; Robert V Stahelin; Emmanuel Skordalakes; Suriyan Ponnusamy; Elizabeth Garrett-Mayer; Charles D Smith; Besim Ogretmen
Journal:  Sci Signal       Date:  2015-06-16       Impact factor: 8.192

4.  Expression and function of muscarinic receptor subtypes on human cornea and conjunctiva.

Authors:  Shaohui Liu; Jing Li; Donald T H Tan; Roger W Beuerman
Journal:  Invest Ophthalmol Vis Sci       Date:  2007-07       Impact factor: 4.799

5.  Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis.

Authors:  Kelley M Argraves; Brent A Wilkerson; W Scott Argraves; Paul A Fleming; Lina M Obeid; Christopher J Drake
Journal:  J Biol Chem       Date:  2004-09-17       Impact factor: 5.157

Review 6.  Neural regulation of lacrimal gland secretory processes: relevance in dry eye diseases.

Authors:  Darlene A Dartt
Journal:  Prog Retin Eye Res       Date:  2009-04-17       Impact factor: 21.198

Review 7.  Role of sphingolipids in senescence: implication in aging and age-related diseases.

Authors:  Magali Trayssac; Yusuf A Hannun; Lina M Obeid
Journal:  J Clin Invest       Date:  2018-07-02       Impact factor: 14.808

Review 8.  Lipid conformational order and the etiology of cataract and dry eye.

Authors:  Douglas Borchman
Journal:  J Lipid Res       Date:  2021-02-06       Impact factor: 5.922

9.  Modulation of Specific Sensory Cortical Areas by Segregated Basal Forebrain Cholinergic Neurons Demonstrated by Neuronal Tracing and Optogenetic Stimulation in Mice.

Authors:  Irene Chaves-Coira; Natali Barros-Zulaica; Margarita Rodrigo-Angulo; Ángel Núñez
Journal:  Front Neural Circuits       Date:  2016-04-20       Impact factor: 3.492

10.  Optogenetic Stimulation of Cholinergic Amacrine Cells Improves Capillary Blood Flow in Diabetic Retinopathy.

Authors:  Elena Ivanova; Paola Bianchimano; Carlo Corona; Cyril G Eleftheriou; Botir T Sagdullaev
Journal:  Invest Ophthalmol Vis Sci       Date:  2020-08-03       Impact factor: 4.799

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  1 in total

1.  Alpha-Glycerylphosphorylcholine and D-Panthenol Eye Drops in Patients Undergoing Cataract Surgery.

Authors:  Gianluca Martone; Alessandra Balestrazzi; Giorgio Ciprandi; Angelo Balestrazzi
Journal:  J Ophthalmol       Date:  2022-06-07       Impact factor: 1.974

  1 in total

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