Background: Cutaneous melanoma is the most aggressive form of skin cancer, with the worst prognosis, and it affects a younger population than most cancers. The high metastatic index, in more advanced stages, and the high aggressiveness decrease the effectiveness of currently used therapies, such as surgical removal, radiotherapy, cryotherapy, and chemotherapy, used alone or in combination. Based on these disadvantages, research focused on alternative medicine offers great potential for therapeutic innovation. Medicinal plants represent a remarkable source of compounds for the treatment of various diseases. Methods: In this study, we investigated the tumoral behavior of melanoma under treatment with the compounds baccarin and p-coumaric acid, extracted from green propolis, in mice inoculated with B16F10 cells for 26 days. Results: A significant modulation in the number of inflammatory cells recruited to the tumor region and blood in the groups treated with the compounds was observed. In addition, a significant reduction in the amount of blood vessels and mitosis in the neoplastic area was noticed. Conclusions: Through our research, we confirmed that baccarin and coumaric acid, isolated substances from Brazilian green propolis, have a promising anticarcinogenic potential to be explored for the development of new antitumor agents, adhering to the trend of drugs with greater tolerance and biological effectiveness.
Background: Cutaneous melanoma is the most aggressive form of skin cancer, with the worst prognosis, and it affects a younger population than most cancers. The high metastatic index, in more advanced stages, and the high aggressiveness decrease the effectiveness of currently used therapies, such as surgical removal, radiotherapy, cryotherapy, and chemotherapy, used alone or in combination. Based on these disadvantages, research focused on alternative medicine offers great potential for therapeutic innovation. Medicinal plants represent a remarkable source of compounds for the treatment of various diseases. Methods: In this study, we investigated the tumoral behavior of melanoma under treatment with the compounds baccarin and p-coumaric acid, extracted from green propolis, in mice inoculated with B16F10 cells for 26 days. Results: A significant modulation in the number of inflammatory cells recruited to the tumor region and blood in the groups treated with the compounds was observed. In addition, a significant reduction in the amount of blood vessels and mitosis in the neoplastic area was noticed. Conclusions: Through our research, we confirmed that baccarin and coumaric acid, isolated substances from Brazilian green propolis, have a promising anticarcinogenic potential to be explored for the development of new antitumor agents, adhering to the trend of drugs with greater tolerance and biological effectiveness.
Entities:
Keywords:
baccarin; cancer therapy; coumaric acid; melanoma; skin cancer
Authors: Brenda K Edwards; Holly L Howe; Lynn A G Ries; Michael J Thun; Harry M Rosenberg; Rosemary Yancik; Phyllis A Wingo; Ahmedin Jemal; Ellen G Feigal Journal: Cancer Date: 2002-05-15 Impact factor: 6.860
Authors: Jianda Yuan; Jun Zhou; Zhiwan Dong; Sapna Tandon; Deborah Kuk; Katherine S Panageas; Philip Wong; Xinqi Wu; Jarushka Naidoo; David B Page; Jedd D Wolchok; F Stephen Hodi Journal: Cancer Immunol Res Date: 2014-02 Impact factor: 11.151
Authors: Luiza D C Lima; Silvia P Andrade; Paula P Campos; Lucíola S Barcelos; Frederico M Soriani; Sandra A L Moura; Mônica A N D Ferreira Journal: BMC Complement Altern Med Date: 2014-05-29 Impact factor: 3.659
Authors: Lih Yin Tan; Carmela Martini; Zvi G Fridlender; Claudine S Bonder; Michael P Brown; Lisa M Ebert Journal: Clin Transl Immunology Date: 2017-03-17