| Literature DB >> 33945798 |
Rupinder Kaur1, J Dylan Shropshire2, Karissa L Cross2, Brittany Leigh2, Alexander J Mansueto2, Victoria Stewart2, Sarah R Bordenstein2, Seth R Bordenstein3.
Abstract
The most widespread intracellular bacteria in the animal kingdom are maternally inherited endosymbionts of the genus Wolbachia. Their prevalence in arthropods and nematodes worldwide and stunning arsenal of parasitic and mutualistic adaptations make these bacteria a biological archetype for basic studies of symbiosis and applied outcomes for curbing human and agricultural diseases. Here, we conduct a summative, centennial analysis of living in the Wolbachia world. We synthesize literature on Wolbachia's host range, phylogenetic diversity, genomics, cell biology, and applications to filarial, arboviral, and agricultural diseases. We also review the mobilome of Wolbachia including phage WO and its essentiality to hallmark reproductive phenotypes in arthropods. Finally, the Wolbachia system is an exemplar for discovery-based science education using biodiversity, biotechnology, and bioinformatics lessons. As we approach a century of Wolbachia research, the interdisciplinary science of this symbiosis stands as a model for consolidating and teaching the integrative rules of endosymbiotic life.Entities:
Keywords: Wolbachia; cytoplasmic incompatibility; evolution; feminization; male killing; parthenogenesis; phage WO; vector control
Mesh：
Year: 2021 PMID： 33945798 PMCID： PMC8192442 DOI： 10.1016/j.chom.2021.03.006
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 31.316