Literature DB >> 3394576

Gastroprotective effect of pentacaine: role of mast cells.

V Nosálová1, M Zaviacic, J Jakubovský, A Babulová, S Polák.   

Abstract

Pentacaine was found to prevent the development of acute haemorrhagic lesions induced by ethanol in rats in a dose-dependent way. Electron microscopy in the untreated group showed extensive disruption of the surface epithelium and deep necrosis of the mucosa after ethanol exposure. Degranulation or even complete destruction of mast cells was observed. The microvasculature exhibited several signs of derangement. After pentacaine treatment, these signs were absent and no degranulation of mucosal mast cells was observed. The mast cell-mediated effect of pentacaine appears to be only one component of its gastroprotective action.

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Year:  1988        PMID： 3394576     DOI： 10.1007/bf02142565

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  6 in total

1.  On the interaction of local anesthetics with mast cells.

Authors:  K Drábiková; R Nosál
Journal:  Agents Actions       Date:  1987-04

2.  Effects of absolute ethanol, misoprostol, cimetidine, and phosphate buffer on the morphology of rat gastric mucosae.

Authors:  E R Lacy
Journal:  Dig Dis Sci       Date:  1986-02       Impact factor: 3.199

3.  Alkoxycarbanilic acid esters with high local anaesthetic activity.

Authors:  L Benes; A Borovanský; L Kopácová
Journal:  Arzneimittelforschung       Date:  1969-11

4.  Effects of FPL-52694, a new mast cell stabilizer, on gastric secretion and various acute gastric lesions in rats.

Authors:  K Takeuchi; Y Ishihara; H Kunimi; S Okabe
Journal:  Agents Actions       Date:  1984-06

5.  Alterations in blood vessels during gastric injury and protection.

Authors:  S Szabo; G Pihan; J S Trier
Journal:  Scand J Gastroenterol Suppl       Date:  1986

6.  Prostaglandin cytoprotection against ethanol-induced gastric injury in the rat. A histologic and cytologic study.

Authors:  K L Schmidt; J M Henagan; G S Smith; P J Hilburn; T A Miller
Journal:  Gastroenterology       Date:  1985-03       Impact factor: 22.682
  6 in total
  3 in total

1.  Gastroprotective and ulcer healing profile of the mast cell stabilizer quazolast in rats.

Authors:  L R Fitzpatrick; D L Decktor
Journal:  Agents Actions       Date:  1991-07

2.  The influence of acute or chronic nicotine treatment on ethanol-induced gastric mucosal damage in rats.

Authors:  C H Cho; B W Chen; W M Hui; S K Lam
Journal:  Dig Dis Sci       Date:  1990-01       Impact factor: 3.199

Review 3.  Chiral Aspects of Local Anesthetics.

Authors:  Ružena Čižmáriková; Jozef Čižmárik; Jindra Valentová; Ladislav Habala; Mário Markuliak
Journal:  Molecules       Date:  2020-06-12       Impact factor: 4.411
  3 in total

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