Daniela A Pereira1, Valeria C Sandrim2, Ana C Palei3, Lorena M Amaral4, Vanessa A Belo1, Riccardo Lacchini5, Ricardo C Cavalli6, Jose E Tanus-Santos7, Marcelo R Luizon1,8. 1. Graduate Program in Genetics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. 2. Department of Biophysics & Pharmacology, Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo, Brazil. 3. Department of Surgery, University of Mississippi Medical Center, Jackson, MS 392164, USA. 4. Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, MS 392164, USA. 5. Department of Psychiatric Nursing & Human Sciences, Ribeirao Preto College of Nursing, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil. 6. Department of Gynecology & Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil. 7. Department of Pharmacology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil. 8. Department of Genetics, Ecology & Evolution, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Abstract
Aim: We examined the relationships between visfatin/NAMPT and nitrite concentrations (a marker of nitric oxide [NO] formation) or sFlt-1 levels in 205 patients with preeclampsia (PE) responsive or nonresponsive to antihypertensive therapy, and whether NAMPT SNPs rs1319501 and rs3801266 affect nitrite concentrations in PE and 206 healthy pregnant women. Patients & methods: Circulating visfatin/NAMPT and sFlt-1 levels were measured by ELISA, and nitrite concentrations by using an ozone-based chemiluminescence assay. Results: In nonresponsive PE patients, visfatin/NAMPT levels were inversely related to nitrite concentrations and positively related to sFlt-1 levels. NAMPT SNP rs1319501 affected nitrite concentrations in nonresponsive PE patients and was tightly linked with NAMPT functional SNPs in Europeans. Conclusion: NAMPT SNP rs1319501 and visfatin/NAMPT affect NO formation, sFlt-1 levels and antihypertensive therapy response in PE.
Aim: We examined the relationships between visfatin/NAMPT and nitrite concentrations (a marker of nitric oxide [NO] formation) or sFlt-1 levels in 205 patients with preeclampsia (PE) responsive or nonresponsive to antihypertensive therapy, and whether NAMPT SNPs rs1319501 and rs3801266 affect nitrite concentrations in PE and 206 healthy pregnant women. Patients & methods: Circulating visfatin/NAMPT and sFlt-1 levels were measured by ELISA, and nitrite concentrations by using an ozone-based chemiluminescence assay. Results: In nonresponsive PE patients, visfatin/NAMPT levels were inversely related to nitrite concentrations and positively related to sFlt-1 levels. NAMPT SNP rs1319501 affected nitrite concentrations in nonresponsive PE patients and was tightly linked with NAMPT functional SNPs in Europeans. Conclusion: NAMPT SNP rs1319501 and visfatin/NAMPT affect NO formation, sFlt-1 levels and antihypertensive therapy response in PE.
Authors: M R Luizon; A C T Palei; V A Belo; L M Amaral; R Lacchini; G Duarte; R C Cavalli; V C Sandrim; J E Tanus-Santos Journal: Pharmacogenomics J Date: 2016-05-10 Impact factor: 3.550
Authors: A C T Palei; V C Sandrim; L M Amaral; J S R Machado; R C Cavalli; R Lacchini; G Duarte; J E Tanus-Santos Journal: Pharmacogenomics J Date: 2011-07-19 Impact factor: 3.550
Authors: Xiaoguang Sun; Venkateswaran Ramamoorthi Elangovan; Brandon Mapes; Sara M Camp; Saad Sammani; Laleh Saadat; Ermelinda Ceco; Shwu-Fan Ma; Carlos Flores; Matthew S MacDougall; Hector Quijada; Bin Liu; Carrie L Kempf; Ting Wang; Eddie T Chiang; Joe G N Garcia Journal: Am J Respir Cell Mol Biol Date: 2014-11 Impact factor: 6.914
Authors: Susana Vallejo; Tania Romacho; Javier Angulo; Laura A Villalobos; Elena Cercas; Alejandra Leivas; Elena Bermejo; Raffaele Carraro; Carlos F Sánchez-Ferrer; Concepción Peiró Journal: PLoS One Date: 2011-11-03 Impact factor: 3.240