Literature DB >> 33941517

Emergence of W272C Substitution in Hmg1 in a Triazole-Resistant Isolate of Aspergillus fumigatus from a Chinese Patient with Chronic Cavitary Pulmonary Aspergillosis.

Tianyu Liang1, Xinyu Yang1, Ruoyu Li1, Ence Yang2, Qiqi Wang1, Nir Osherov3, Wei Chen1, Zhe Wan1, Wei Liu1.   

Abstract

Recently, mutations in the 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase gene (hmg1) have been identified to be associated with triazole resistance in Aspergillus fumigatus. Here, we describe the first case of the G929C mutation in the hmg1 gene, leading to the W272C amino acid substitution, in a triazole-resistant isolate of A. fumigatus recovered from a chronic cavitary pulmonary aspergillosis patient who failed voriconazole therapy in China.

Entities:  

Keywords:  Aspergillus fumigatus; W272C substitution; hmg1 mutation; triazole resistance

Mesh：

Substances：

Year:  2021        PMID： 33941517      PMCID： PMC8218700          DOI： 10.1128/AAC.00263-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

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Journal:  Med Mycol       Date:  2021-04-06       Impact factor: 4.076

2.  Glucose controls phosphoregulation of hydroxymethylglutaryl coenzyme A reductase through the protein phosphatase 2A-related phosphatase protein, Ppe1, and Insig in fission yeast.

Authors:  John S Burg; Peter J Espenshade
Journal:  J Biol Chem       Date:  2011-06-16       Impact factor: 5.157

3.  Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline.

Authors:  A J Ullmann; J M Aguado; S Arikan-Akdagli; D W Denning; A H Groll; K Lagrou; C Lass-Flörl; R E Lewis; P Munoz; P E Verweij; A Warris; F Ader; M Akova; M C Arendrup; R A Barnes; C Beigelman-Aubry; S Blot; E Bouza; R J M Brüggemann; D Buchheidt; J Cadranel; E Castagnola; A Chakrabarti; M Cuenca-Estrella; G Dimopoulos; J Fortun; J-P Gangneux; J Garbino; W J Heinz; R Herbrecht; C P Heussel; C C Kibbler; N Klimko; B J Kullberg; C Lange; T Lehrnbecher; J Löffler; O Lortholary; J Maertens; O Marchetti; J F Meis; L Pagano; P Ribaud; M Richardson; E Roilides; M Ruhnke; M Sanguinetti; D C Sheppard; J Sinkó; A Skiada; M J G T Vehreschild; C Viscoli; O A Cornely
Journal:  Clin Microbiol Infect       Date:  2018-03-12       Impact factor: 8.067

4.  The cdr1B efflux transporter is associated with non-cyp51a-mediated itraconazole resistance in Aspergillus fumigatus.

Authors:  Marcin G Fraczek; Michael Bromley; Ahmed Buied; Caroline B Moore; Ranjith Rajendran; Riina Rautemaa; Gordon Ramage; David W Denning; Paul Bowyer
Journal:  J Antimicrob Chemother       Date:  2013-04-10       Impact factor: 5.790

5.  Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America.

Authors:  Thomas F Patterson; George R Thompson; David W Denning; Jay A Fishman; Susan Hadley; Raoul Herbrecht; Dimitrios P Kontoyiannis; Kieren A Marr; Vicki A Morrison; M Hong Nguyen; Brahm H Segal; William J Steinbach; David A Stevens; Thomas J Walsh; John R Wingard; Jo-Anne H Young; John E Bennett
Journal:  Clin Infect Dis       Date:  2016-06-29       Impact factor: 9.079

6.  Antifungal activity of statins against Aspergillus species.

Authors:  Jianjun Qiao; Dimitrios P Kontoyiannis; Zhe Wan; Ruoyu Li; Wei Liu
Journal:  Med Mycol       Date:  2007-11       Impact factor: 4.076

7.  Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.

Authors:  J W M van der Linden; M C Arendrup; A Warris; K Lagrou; H Pelloux; P M Hauser; E Chryssanthou; E Mellado; S E Kidd; A M Tortorano; E Dannaoui; P Gaustad; J W Baddley; A Uekötter; C Lass-Flörl; N Klimko; C B Moore; D W Denning; A C Pasqualotto; C Kibbler; S Arikan-Akdagli; D Andes; J Meletiadis; L Naumiuk; M Nucci; W J G Melchers; P E Verweij
Journal:  Emerg Infect Dis       Date:  2015-06       Impact factor: 6.883

8.  Mutations in hmg1, Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus.

Authors:  P David Rogers; Jarrod R Fortwendel; Jeffrey M Rybak; Wenbo Ge; Nathan P Wiederhold; Josie E Parker; Steven L Kelly
Journal:  mBio       Date:  2019-04-02       Impact factor: 7.867

9.  Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase.

Authors:  Daisuke Hagiwara; Teppei Arai; Hiroki Takahashi; Yoko Kusuya; Akira Watanabe; Katsuhiko Kamei
Journal:  Emerg Infect Dis       Date:  2018-10       Impact factor: 6.883
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  2 in total

Review 1.  Molecular mechanisms of acquired antifungal drug resistance in principal fungal pathogens and EUCAST guidance for their laboratory detection and clinical implications.

Authors:  Thomas R Rogers; Paul E Verweij; Mariana Castanheira; Eric Dannaoui; P Lewis White; Maiken Cavling Arendrup
Journal:  J Antimicrob Chemother       Date:  2022-07-28       Impact factor: 5.758

2.  Triazole-Resistant Aspergillus fumigatus in an Israeli Patient with Chronic Cavitary Pulmonary Aspergillosis Due to a Novel E306K Substitution in Hmg1.

Authors:  Mariana Handelman; Alma Morogovsky; Wei Liu; Ronen Ben-Ami; Nir Osherov
Journal:  Antimicrob Agents Chemother       Date:  2021-07-19       Impact factor: 5.191
  2 in total

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