Petar Cabunac1, Nataša Karadžov Orlić1,2, Daniela Ardalić3, Gorica Banjac3, Jasmina Ivanišević4, Jelena Janać4, Jelena Vekić4, Aleksandra Zeljković4, Marija Mihajlović4, Nina Rajović5, Nataša Milić5,6, Željko Miković1,2. 1. Department of High-Risk Pregnancy, Clinic of Gynecology and Obstetrics "Narodni Front", Belgrade, Serbia. 2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia. 3. Department of Medical Biochemistry, Clinic of Gynecology and Obstetrics "Narodni Front", Belgrade, Serbia. 4. Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia. 5. Institute for Medical Statistics and Informatics, University of Belgrade, Belgrade, Serbia. 6. Division of Nephrology and Hypertension, Mayo Clinic, Rochester, USA.
Abstract
OBJECTIVE: The aim of the study was to assess the potential role of oxidative stress and lipid status in the onset of preeclampsia. METHODS: 138 high-risk pregnant women were prospectively followed. Assessment of oxidative stress (TAS, TOS, AOPP and SH groups) and lipid status (t-C, LDL-C, HDL-C, TGC, APO-A1, APO-B) was carried out during the pregnancy. RESULTS: 30 women developed preeclampsia. TGC, atherogenic index of plasma, TAS and SH levels were higher in women who subsequently developed preeclampsia (p<0.05). CONCLUSION: Oxidative stress and lipid status disturbance have a potential role in the onset of preeclampsia in high risk pregnancies.
OBJECTIVE: The aim of the study was to assess the potential role of oxidative stress and lipid status in the onset of preeclampsia. METHODS: 138 high-risk pregnant women were prospectively followed. Assessment of oxidative stress (TAS, TOS, AOPP and SH groups) and lipid status (t-C, LDL-C, HDL-C, TGC, APO-A1, APO-B) was carried out during the pregnancy. RESULTS: 30 women developed preeclampsia. TGC, atherogenic index of plasma, TAS and SH levels were higher in women who subsequently developed preeclampsia (p<0.05). CONCLUSION: Oxidative stress and lipid status disturbance have a potential role in the onset of preeclampsia in high risk pregnancies.
Authors: Jelena Vekic; Aleksandra Zeljkovic; Arrigo F G Cicero; Andrej Janez; Anca Pantea Stoian; Alper Sonmez; Manfredi Rizzo Journal: Medicina (Kaunas) Date: 2022-02-16 Impact factor: 2.430