M M Lokhorst1, S E R Horbach1, D A Young-Afat1, M L E Stor1, L Haverman2, P I Spuls3, C M A M van der Horst1. 1. Department of Plastic, Reconstructive and Hand Surgery, Amsterdam University Medical Centers, Amsterdam, The Netherlands. 2. Psychosocial Department, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands. 3. Department of Dermatology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Public Health, Infection and Immunity, Amsterdam, The Netherlands.
Abstract
BACKGROUND: The symptoms and appearance of vascular malformations can severely harm a patient's quality of life. The aim of treatment of vascular malformations generally is to improve condition-specific symptoms and/or appearance. Therefore, it is highly important to start testing treatment effects in clinical studies from the patient's perspective. OBJECTIVES: The objective of this study was to develop a patient-reported outcome measure (PROM) for measuring symptoms and appearance in patients with vascular malformations. METHODS: A first draft of the PROM was based on the previously internationally developed core outcome set. The qualitative part of this study involved interviews with 14 patients, which led to a second draft. The second draft was field-tested cross-sectionally, after which groups of items were evaluated for adequate internal consistency (Cronbach's alpha >0.7) to form composite scores. Construct validity was evaluated by testing 13 predefined hypotheses on known-group differences. RESULTS: The patient interviews ensured adequate content validity and resulted in a general symptom scale with 6 items, head/neck symptom scale with 8 items and an appearance scale with 9 items. Cronbach's alpha was adequate for two composite scores: a general symptom score (0.88) and an appearance score (0.85). Ten out of 13 hypotheses on known-group differences were confirmed, confirming adequate construct validity. CONCLUSIONS: With the development of the OVAMA questionnaire, outcomes of patients with vascular malformations can now be evaluated from the patients' perspective. This may help improve the development of evidence-based treatments and the overall care for patients with vascular malformations. This article is protected by copyright. All rights reserved.
BACKGROUND: The symptoms and appearance of vascular malformations can severely harm a patient's quality of life. The aim of treatment of vascular malformations generally is to improve condition-specific symptoms and/or appearance. Therefore, it is highly important to start testing treatment effects in clinical studies from the patient's perspective. OBJECTIVES: The objective of this study was to develop a patient-reported outcome measure (PROM) for measuring symptoms and appearance in patients with vascular malformations. METHODS: A first draft of the PROM was based on the previously internationally developed core outcome set. The qualitative part of this study involved interviews with 14 patients, which led to a second draft. The second draft was field-tested cross-sectionally, after which groups of items were evaluated for adequate internal consistency (Cronbach's alpha >0.7) to form composite scores. Construct validity was evaluated by testing 13 predefined hypotheses on known-group differences. RESULTS: The patient interviews ensured adequate content validity and resulted in a general symptom scale with 6 items, head/neck symptom scale with 8 items and an appearance scale with 9 items. Cronbach's alpha was adequate for two composite scores: a general symptom score (0.88) and an appearance score (0.85). Ten out of 13 hypotheses on known-group differences were confirmed, confirming adequate construct validity. CONCLUSIONS: With the development of the OVAMA questionnaire, outcomes of patients with vascular malformations can now be evaluated from the patients' perspective. This may help improve the development of evidence-based treatments and the overall care for patients with vascular malformations. This article is protected by copyright. All rights reserved.