Jing Yuan1, Cindy Xue1, Gladys Lo2, Oi Lei Wong1, Yihang Zhou1, Siu Ki Yu1, Kin Yin Cheung1. 1. Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong, Hong Kong SAR, China. 2. Department of Diagnostic & Interventional Radiology, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong, Hong Kong SAR, China.
Abstract
BACKGROUND: MRI pulse sequences and imaging parameters substantially influence the variation of MRI radiomics features, thus impose a critical challenge on MRI radiomics reproducibility and reliability. This study aims to prospectively investigate the impact of various imaging parameters on MRI radiomics features in a 3D T2-weighted (T2W) turbo-spin-echo (TSE) pulse sequence for MR-guided-radiotherapy (MRgRT). METHODS: An anthropomorphic phantom was scanned using a 3D-T2W-TSE MRgRT sequence at 1.5T under a variety of acquisition imaging parameter changes. T1 and T2 relaxation times of the phantom were also measured. 93 first-order and texture radiomics features in the original and 14 transformed images, yielding 1,395 features in total, were extracted from 10 volumes-of-interest (VOIs). The percentage deviation (d%) of radiomics feature values from the baseline values and intra-class correlation coefficient (ICC) with the baseline were calculated. Robust radiomics features were identified based on the excellent agreement of radiomics feature values with the baseline, i.e., the averaged d% <5% and ICC >0.90 in all VOIs for all imaging parameter variations. RESULTS: The radiomics feature values changed considerably but to different degrees with different imaging parameter adjustments, in the ten VOIs. The deviation d% ranged from 0.02% to 321.3%, with a mean of 12.5% averaged for all original features in all ten VOIs. First-order and GLCM features were generally more robust to imaging parameters than other features in the original images. There were also significantly different radiomics feature values (ANOVA, P<0.001) between the original and the transformed images, exhibiting quite different robustness to imaging parameters. 330 out of 1395 features (23.7%) robust to imaging parameters were identified. GLCM and GLSZM features had the most (42.5%, 153/360) and least (3.8%, 9/240) robust features in the original and transformed images, respectively. CONCLUSIONS: This study helps better understand the quantitative dependence of radiomics feature values on imaging parameters in a 3D-T2W-TSE sequence for MRgRT. Imaging parameter heterogeneity should be considered as a significant source of radiomics variability and uncertainty, which must be well harmonized for reliable clinical use. The identified robust features to imaging parameters are helpful for the pre-selection of radiomics features for reliable radiomics modeling. 2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
BACKGROUND: MRI pulse sequences and imaging parameters substantially influence the variation of MRI radiomics features, thus impose a critical challenge on MRI radiomics reproducibility and reliability. This study aims to prospectively investigate the impact of various imaging parameters on MRI radiomics features in a 3D T2-weighted (T2W) turbo-spin-echo (TSE) pulse sequence for MR-guided-radiotherapy (MRgRT). METHODS: An anthropomorphic phantom was scanned using a 3D-T2W-TSE MRgRT sequence at 1.5T under a variety of acquisition imaging parameter changes. T1 and T2 relaxation times of the phantom were also measured. 93 first-order and texture radiomics features in the original and 14 transformed images, yielding 1,395 features in total, were extracted from 10 volumes-of-interest (VOIs). The percentage deviation (d%) of radiomics feature values from the baseline values and intra-class correlation coefficient (ICC) with the baseline were calculated. Robust radiomics features were identified based on the excellent agreement of radiomics feature values with the baseline, i.e., the averaged d% <5% and ICC >0.90 in all VOIs for all imaging parameter variations. RESULTS: The radiomics feature values changed considerably but to different degrees with different imaging parameter adjustments, in the ten VOIs. The deviation d% ranged from 0.02% to 321.3%, with a mean of 12.5% averaged for all original features in all ten VOIs. First-order and GLCM features were generally more robust to imaging parameters than other features in the original images. There were also significantly different radiomics feature values (ANOVA, P<0.001) between the original and the transformed images, exhibiting quite different robustness to imaging parameters. 330 out of 1395 features (23.7%) robust to imaging parameters were identified. GLCM and GLSZM features had the most (42.5%, 153/360) and least (3.8%, 9/240) robust features in the original and transformed images, respectively. CONCLUSIONS: This study helps better understand the quantitative dependence of radiomics feature values on imaging parameters in a 3D-T2W-TSE sequence for MRgRT. Imaging parameter heterogeneity should be considered as a significant source of radiomics variability and uncertainty, which must be well harmonized for reliable clinical use. The identified robust features to imaging parameters are helpful for the pre-selection of radiomics features for reliable radiomics modeling. 2021 Quantitative Imaging in Medicine and Surgery. All rights reserved.
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