Patient-Specific Modeling with Personalized Decision Paths.

Predictive models can be useful in predicting patient outcomes under uncertainty. Many algorithms employ "population" methods, which optimize a single model to perform well on average over an entire population, but the model may perform poorly on some patients. Personalized methods optimize predictive performance for each patient by tailoring the model to the individual. We present a new personalized method based on decision trees: the Personalized Decision Path using a Bayesian score (PDP-Bay). Performance on eight synthetic, genomic, and clinical datasets was compared to that of decision trees and a previously described personalized decision path method in terms of area under the ROC curve (AUC) and expected calibration error (ECE). Model complexity was measured by average path length. The PDP-Bay model outperformed the decision tree in terms of both AUC and ECE. The results support the conclusion that personalization may achieve better predictive performance and produce simpler models than population approaches. ©2020 AMIA - All rights reserved.