Literature DB >> 33936410

Catch Me if You Can: Acute Events Hidden in Structured Chronic Disease Diagnosis Descriptions Show Detectable Recording Patterns in EHR.

Franck Diaz-Garelli1, Kristin M Lenoir2, Brian J Wells2.   

Abstract

Our previous research shows that structured cancer DX description data accuracy varied across electronic health record (EHR) segments (e.g. encounter DX, problem list, etc.). We provide initial evidence corroborating these findings in EHRs from patients with diabetes. We hypothesized that the odds of recording an "uncontrolled diabetes" DX increased after a hemoglobin A1c result above 9% and that this rate would vary across EHR segments. Our statistical models revealed that each DX indicating uncontrolled diabetes was 2.6% more likely to occur post-A1c>9% overall (adj-p=.0005) and 3.9% after controlling for EHR segment (adj-p<.0001). However, odds ratios varied across segments (1.021<OR<1.224, .0001<adj-p<.087). The number of providers (adj-p<.0001) and departments (adjp<.0001) also impacted the number of DX reporting uncontrolled diabetes. Segment heterogeneity must be accounted for when analyzing clinical data. Understanding this phenomenon will support accuracy-driven EHR data extraction to foster reliable secondary analyses of EHR data. ©2020 AMIA - All rights reserved.

Entities:  

Year:  2021        PMID: 33936410      PMCID: PMC8075503     

Source DB:  PubMed          Journal:  AMIA Annu Symp Proc        ISSN: 1559-4076


  51 in total

1.  Akaike's information criterion in generalized estimating equations.

Authors:  W Pan
Journal:  Biometrics       Date:  2001-03       Impact factor: 2.571

2.  Using routinely collected data for clinical research.

Authors:  C Safran
Journal:  Stat Med       Date:  1991-04       Impact factor: 2.373

3.  Adjusting for multiple testing when reporting research results: the Bonferroni vs Holm methods.

Authors:  M Aickin; H Gensler
Journal:  Am J Public Health       Date:  1996-05       Impact factor: 9.308

Review 4.  The global burden of diabetes and its complications: an emerging pandemic.

Authors:  Susan van Dieren; Joline W J Beulens; Yvonne T van der Schouw; Diederick E Grobbee; Bruce Neal
Journal:  Eur J Cardiovasc Prev Rehabil       Date:  2010-05

Review 5.  Reuse of clinical data.

Authors:  C Safran
Journal:  Yearb Med Inform       Date:  2014-08-15

6.  Caveats for the use of operational electronic health record data in comparative effectiveness research.

Authors:  William R Hersh; Mark G Weiner; Peter J Embi; Judith R Logan; Philip R O Payne; Elmer V Bernstam; Harold P Lehmann; George Hripcsak; Timothy H Hartzog; James J Cimino; Joel H Saltz
Journal:  Med Care       Date:  2013-08       Impact factor: 2.983

Review 7.  Methods and dimensions of electronic health record data quality assessment: enabling reuse for clinical research.

Authors:  Nicole Gray Weiskopf; Chunhua Weng
Journal:  J Am Med Inform Assoc       Date:  2012-06-25       Impact factor: 4.497

8.  Secondary Use of EHR: Data Quality Issues and Informatics Opportunities.

Authors:  Taxiarchis Botsis; Gunnar Hartvigsen; Fei Chen; Chunhua Weng
Journal:  Summit Transl Bioinform       Date:  2010-03-01

Review 9.  Reconciling evidence-based medicine and precision medicine in the era of big data: challenges and opportunities.

Authors:  Jacques S Beckmann; Daniel Lew
Journal:  Genome Med       Date:  2016-12-19       Impact factor: 11.117

10.  Biopsy Records Do Not Reduce Diagnosis Variability in Cancer Patient EHRs: Are We More Uncertain After Knowing?

Authors:  Jose-Franck Diaz-Garelli; Brian J Wells; Caleb Yelton; Roy Strowd; Umit Topaloglu
Journal:  AMIA Jt Summits Transl Sci Proc       Date:  2018-05-18
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