Literature DB >> 33934711

Differentiation, functions, and roles of T follicular regulatory cells in autoimmune diseases.

He Hao1,2, Shingo Nakayamada1, Yoshiya Tanaka3.   

Abstract

T follicular helper cells participate in stimulating germinal center (GC) formation and supporting B cell differentiation and autoantibody production. However, T follicular regulatory (Tfr) cells suppress B cell activation. Since changes in the number and functions of Tfr cells lead to dysregulated GC reaction and autoantibody response, targeting Tfr cells may benefit the treatment of autoimmune diseases. Differentiation of Tfr cells is a multistage and multifactorial process with various positive and negative regulators. Therefore, understanding the signals regulating Tfr cell generation is crucial for the development of targeted therapies. In this review, we discuss recent studies that have elucidated the roles of Tfr cells in autoimmune diseases and investigated the modulators of Tfr cell differentiation. Additionally, potential immunotherapies targeting Tfr cells are highlighted.

Entities:  

Keywords:  Autoimmune diseases; Differentiation; T follicular helper cells; T follicular regulatory cells; Therapeutic targets

Year:  2021        PMID： 33934711     DOI： 10.1186/s41232-021-00164-9

Source DB:  PubMed          Journal:  Inflamm Regen        ISSN： 1880-8190


  72 in total

Review 1.  T follicular helper cell differentiation, function, and roles in disease.

Authors:  Shane Crotty
Journal:  Immunity       Date:  2014-10-16       Impact factor: 31.745

2.  Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells.

Authors:  Ivonne Wollenberg; Ana Agua-Doce; Andrea Hernández; Catarina Almeida; Vanessa G Oliveira; Jose Faro; Luis Graca
Journal:  J Immunol       Date:  2011-10-07       Impact factor: 5.422

3.  Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses.

Authors:  Hyung W Lim; Peter Hillsamer; Chang H Kim
Journal:  J Clin Invest       Date:  2004-12       Impact factor: 14.808

4.  Circulating T follicular regulatory and helper cells have memory-like properties.

Authors:  Peter T Sage; David Alvarez; Jernej Godec; Ulrich H von Andrian; Arlene H Sharpe
Journal:  J Clin Invest       Date:  2014-10-27       Impact factor: 14.808

5.  A distinct subpopulation of CD25- T-follicular regulatory cells localizes in the germinal centers.

Authors:  James Badger Wing; Yohko Kitagawa; Michela Locci; Hannah Hume; Christopher Tay; Takayoshi Morita; Yujiro Kidani; Kyoko Matsuda; Takeshi Inoue; Tomohiro Kurosaki; Shane Crotty; Cevayir Coban; Naganari Ohkura; Shimon Sakaguchi
Journal:  Proc Natl Acad Sci U S A       Date:  2017-07-11       Impact factor: 11.205

Review 6.  Follicular helper CD4 T cells (TFH).

Authors:  Shane Crotty
Journal:  Annu Rev Immunol       Date:  2011       Impact factor: 28.527

7.  Early Th1 cell differentiation is marked by a Tfh cell-like transition.

Authors:  Shingo Nakayamada; Yuka Kanno; Hayato Takahashi; Dragana Jankovic; Kristina T Lu; Thomas A Johnson; Hong-wei Sun; Golnaz Vahedi; Ofir Hakim; Robin Handon; Pamela L Schwartzberg; Gordon L Hager; John J O'Shea
Journal:  Immunity       Date:  2011-12-23       Impact factor: 31.745

Review 8.  The role of the innate immune response in autoimmune disease.

Authors:  Karl S Lang; Annika Burow; Michael Kurrer; Philipp A Lang; Mike Recher
Journal:  J Autoimmun       Date:  2007-09-29       Impact factor: 7.094

9.  Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions.

Authors:  Yeonseok Chung; Shinya Tanaka; Fuliang Chu; Roza I Nurieva; Gustavo J Martinez; Seema Rawal; Yi-Hong Wang; Hoyong Lim; Joseph M Reynolds; Xiao-hui Zhou; Hui-min Fan; Zhong-ming Liu; Sattva S Neelapu; Chen Dong
Journal:  Nat Med       Date:  2011-07-24       Impact factor: 53.440

10.  Foxp3+ follicular regulatory T cells control the germinal center response.

Authors:  Michelle A Linterman; Wim Pierson; Sau K Lee; Axel Kallies; Shimpei Kawamoto; Tim F Rayner; Monika Srivastava; Devina P Divekar; Laura Beaton; Jennifer J Hogan; Sidonia Fagarasan; Adrian Liston; Kenneth G C Smith; Carola G Vinuesa
Journal:  Nat Med       Date:  2011-07-24       Impact factor: 53.440
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  4 in total

Review 1.  T Cell Roles and Activity in Chronic Sclerosing Sialadenitis as IgG4-Related Disease: Current Concepts in Immunopathogenesis.

Authors:  Hazim Mahmoud Ibrahem
Journal:  Autoimmune Dis       Date:  2022-06-20

Review 2.  Members of the Regulatory Lymphocyte Club in Common Variable Immunodeficiency.

Authors:  Sudhir Gupta; Yesim Demirdag; Ankmalika Abha Gupta
Journal:  Front Immunol       Date:  2022-05-20       Impact factor: 8.786

Review 3.  Follicular Helper CD4+ T Cells, Follicular Regulatory CD4+ T Cells, and Inducible Costimulator and Their Roles in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.

Authors:  Xue Zhang; Ruli Ge; Hongliang Chen; Maxwell Ahiafor; Bin Liu; Jinbo Chen; Xueli Fan
Journal:  Mediators Inflamm       Date:  2021-09-12       Impact factor: 4.711

4.  Single cell and spatial transcriptomic analyses reveal microglia-plasma cell crosstalk in the brain during Trypanosoma brucei infection.

Authors:  Juan F Quintana; Praveena Chandrasegaran; Matthew C Sinton; Emma M Briggs; Thomas D Otto; Rhiannon Heslop; Calum Bentley-Abbot; Colin Loney; Luis de Lecea; Neil A Mabbott; Annette MacLeod
Journal:  Nat Commun       Date:  2022-09-30       Impact factor: 17.694
  4 in total

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