Yajing Liu1, Lushi Chen1, Shuyun Huang1, Zeping Lv2, Lang Hu1, Jiali Luo1, Pan Shang1, Yukai Wang3, Haiqun Xie4. 1. Department of Neurology, First People's Hospital of Foshan, No.81, Lingnan North Road, Foshan, 528000, Guangdong, China. 2. National Research Center for Rehabilitation Technical Aids, Rehabilitation Hospital, Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, Key Laboratory of Intelligent Control and Rehabilitation Technology of the Ministry of Civil Affairs, Beijing, China. 3. Department of Neurology, First People's Hospital of Foshan, No.81, Lingnan North Road, Foshan, 528000, Guangdong, China. wykai2012@qq.com. 4. Department of Neurology, First People's Hospital of Foshan, No.81, Lingnan North Road, Foshan, 528000, Guangdong, China. haiqunx@foxmail.com.
Abstract
STUDY OBJECTIVES: This study aims to investigate the extent to which sleep duration and efficiency are associated with plasma amyloid-β (Aβ) levels in non-demented older people. METHODS: This study is a cross-sectional analysis of 305 non-demented older people. Sleep duration and efficiency were assessed used the Pittsburgh Sleep Quality Index. Levels of plasma Aβ were determined by sandwich enzyme-linked immunosorbent assay technique. Associations between sleep variables and plasma Aβ levels were evaluated with multivariable linear regression analysis. RESULTS: Compared to those with sleep duration > 7 h, participants with sleep duration < 6 h had a higher plasma Aβ42 level (β = 0.495, 95% CI 0.077~0.913, p = 0.021) and Aβ42/Aβ40 ratio (β = 0.101, 95% CI 0.058~0.144, p < 0.001). Compared to those with sleep efficiency ≥ 85%, participants with lower sleep efficiency (65~74%, <65%) had a higher level of plasma Aβ42 (<65%: β = 0.627, 95% CI 0.147~1.108, p = 0.011) and Aβ42/Aβ40 ratio (65~74%: β = 0.052, 95% CI 0.007~0.097, p = 0.026; <65%: β = 0.117, 95% CI 0.067~0.168, p < 0.001). CONCLUSIONS: These findings indicated that short sleep duration and low sleep efficiency were associated with a high level of Aβ42. A better comprehending of the link between sleep and plasma Aβ levels may lead to effective sleep-based intervention to reduce the risk of Alzheimer's disease.
STUDY OBJECTIVES: This study aims to investigate the extent to which sleep duration and efficiency are associated with plasma amyloid-β (Aβ) levels in non-demented older people. METHODS: This study is a cross-sectional analysis of 305 non-demented older people. Sleep duration and efficiency were assessed used the Pittsburgh Sleep Quality Index. Levels of plasma Aβ were determined by sandwich enzyme-linked immunosorbent assay technique. Associations between sleep variables and plasma Aβ levels were evaluated with multivariable linear regression analysis. RESULTS: Compared to those with sleep duration > 7 h, participants with sleep duration < 6 h had a higher plasma Aβ42 level (β = 0.495, 95% CI 0.077~0.913, p = 0.021) and Aβ42/Aβ40 ratio (β = 0.101, 95% CI 0.058~0.144, p < 0.001). Compared to those with sleep efficiency ≥ 85%, participants with lower sleep efficiency (65~74%, <65%) had a higher level of plasma Aβ42 (<65%: β = 0.627, 95% CI 0.147~1.108, p = 0.011) and Aβ42/Aβ40 ratio (65~74%: β = 0.052, 95% CI 0.007~0.097, p = 0.026; <65%: β = 0.117, 95% CI 0.067~0.168, p < 0.001). CONCLUSIONS: These findings indicated that short sleep duration and low sleep efficiency were associated with a high level of Aβ42. A better comprehending of the link between sleep and plasma Aβ levels may lead to effective sleep-based intervention to reduce the risk of Alzheimer's disease.
Authors: Adam P Spira; Alyssa A Gamaldo; Yang An; Mark N Wu; Eleanor M Simonsick; Murat Bilgel; Yun Zhou; Dean F Wong; Luigi Ferrucci; Susan M Resnick Journal: JAMA Neurol Date: 2013-12 Impact factor: 18.302
Authors: Pedro Pesini; Virginia Pérez-Grijalba; Inmaculada Monleón; Mercè Boada; Lluís Tárraga; Pablo Martínez-Lage; Itziar San-José; Manuel Sarasa Journal: Int J Alzheimers Dis Date: 2012-08-16