Literature DB >> 3393421

Rectal absorption enhancement of rate-controlled delivered ampicillin sodium by sodium decanoate in conscious rats.

E J Van Hoogdalem1, A G De Boer, D D Breimer.   

Abstract

Because of the relatively poor intestinal absorption of ampicillin sodium, efforts have been made to enhance ampicillin absorption by co-administration of absorption promoters. In the present study the enhancing effect of sodium decanoate on rate and extent of rectal ampicillin absorption in rats has been evaluated after rate-controlled and site-controlled delivery of aqueous solutions. Rectal absorption without enhancer was extremely low (8 +/- 7%), and the addition of 0.032 M sodium decanoate gave comparable values. However, administration in 0.16 M decanoate considerably increased ampicillin bioavailability, to 79 +/- 30%, whereas the absorption rate was not significantly affected.

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Year:  1988        PMID： 3393421     DOI： 10.1007/bf01962682

Source DB:  PubMed          Journal:  Pharm Weekbl Sci        ISSN： 0167-6555


  18 in total

1.  Studies on absorption promoters for rectal delivery preparations. I. Promoting efficacy of enamine derivatives of amino acids for the rectal absorption of beta-lactam antibiotics in rabbits.

Authors:  T Murakami; N Yata; H Tamauchi; J Nakai; M Yamazaki; A Kamada
Journal:  Chem Pharm Bull (Tokyo)       Date:  1981-07       Impact factor: 1.645

2.  Determination of benzylpenicillin in plasma and urine by high-performance liquid chromatography.

Authors:  R H Rumble; M S Roberts
Journal:  J Chromatogr       Date:  1985-08-09

3.  Studies on the promoting effects of carboxylic acid derivatives on the rectal absorption of beta-lactam antibiotics in rats.

Authors:  K Nishimura; Y Nozaki; A Yoshimi; S Nakamura; M Kitagawa; N Kakeya; K Kitao
Journal:  Chem Pharm Bull (Tokyo)       Date:  1985-01       Impact factor: 1.645

4.  Rectal delivery of antiinflammatory drugs. III. Effect of basic amino acid salts of diclofenac on the rectal absorption of ampicillin sodium.

Authors:  H Yaginuma; Y Isoda; Y Wada; S Itoh; M Yamazaki; A Kamada; H Shimazu; I Makita
Journal:  Chem Pharm Bull (Tokyo)       Date:  1982-03       Impact factor: 1.645

5.  Critical evaluation of the potential error in pharmacokinetic studies of using the linear trapezoidal rule method for the calculation of the area under the plasma level--time curve.

Authors:  W L Chiou
Journal:  J Pharmacokinet Biopharm       Date:  1978-12

6.  Membrane-disordering potency and anticonvulsant action of valproic acid and other short-chain fatty acids.

Authors:  B J Perlman; D B Goldstein
Journal:  Mol Pharmacol       Date:  1984-07       Impact factor: 4.436

7.  Enhanced rectal absorption of beta-lactam antibiotics in rat by monodesmosides isolated from pericarps of Sapindus mukurossi (Enmei-hi).

Authors:  N Yata; N Sugihara; R Yamajo; T Murakami; Y Higashi; H Kimata; K Nakayama; T Kuzuki; O Tanaka
Journal:  J Pharmacobiodyn       Date:  1985-12

8.  Does calcium mediate slowing of gastric emptying by fat in humans?

Authors:  J N Hunt
Journal:  Am J Physiol       Date:  1983-01

9.  Effect of fatty acids and monoglycerides on permeability of lipid bilayer.

Authors:  N Muranushi; N Takagi; S Muranishi; H Sezaki
Journal:  Chem Phys Lipids       Date:  1981-05       Impact factor: 3.329

10.  Enhanced rectal absorption of sodium ampicillin by N-acyl derivatives of collagen peptide in rabbits and rats.

Authors:  N Yata; W M Wu; R Yamajo; T Murakami; Y Higashi; T Higuchi
Journal:  J Pharm Sci       Date:  1985-10       Impact factor: 3.534
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  3 in total

1.  Water-in-oil microemulsions containing medium-chain fatty acids/salts: formulation and intestinal absorption enhancement evaluation.

Authors:  P P Constantinides; G Welzel; H Ellens; P L Smith; S Sturgis; S H Yiv; A B Owen
Journal:  Pharm Res       Date:  1996-02       Impact factor: 4.200

2.  Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides.

Authors:  P P Constantinides; J P Scalart; C Lancaster; J Marcello; G Marks; H Ellens; P L Smith
Journal:  Pharm Res       Date:  1994-10       Impact factor: 4.200

3.  Mechanism of absorption enhancement in humans after rectal administration of ampicillin in suppositories containing sodium caprate.

Authors:  T Lindmark; J D Söderholm; G Olaison; G Alván; G Ocklind; P Artursson
Journal:  Pharm Res       Date:  1997-07       Impact factor: 4.200
  3 in total

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