Sarah Tebeka1, Yann Le Strat2, Alix De Premorel Higgons2, Alexandra Benachi3, Marc Dommergues4, Gilles Kayem5, Jacques Lepercq6, Dominique Luton7, Laurent Mandelbrot8, Yves Ville9, Nicolas Ramoz10, Sophie Tezenas du Montcel11, Jimmy Mullaert12, Caroline Dubertret2. 1. Université de Paris, INSERM UMR1266, Institute of Psychiatry and Neurosciences, Team 1, Paris, France; Department of Psychiatry, AP-HP, Louis Mourier Hospital, F-92700, Colombes, France. Electronic address: sarah.tebeka@aphp.fr. 2. Université de Paris, INSERM UMR1266, Institute of Psychiatry and Neurosciences, Team 1, Paris, France; Department of Psychiatry, AP-HP, Louis Mourier Hospital, F-92700, Colombes, France. 3. Université Paris Sud, Clamart, France; Department of Obstetrics and Gynecology, AP-HP, Antoine Beclere Hospital, Clamart, France. 4. Sorbonne University, Paris, France; Department of Obstetrics and Gynecology, AP-HP, Hôpital Universitaire Pitié-Salpêtrière, Paris, France. 5. Sorbonne University, Paris, France; Department of Obstetrics and Gynecology, AP-HP, Trousseau Hospital, Paris, France. 6. Université de Paris, Departement Hospitalier Universitaire Risks in Pregnancy, Paris, France; Port-Royal Maternity Unit, Cochin Hospital, AP-HP, Paris, France. 7. Université de Paris, Departement Hospitalier Universitaire Risks in Pregnancy, Paris, France; Department of Obstetrics and Gynecology, AP-HP, Bichat Hospital, Paris, France. 8. Université de Paris, Departement Hospitalier Universitaire Risks in Pregnancy, Paris, France; Department of Obstetrics and Gynecology, AP-HP, Louis Mourier Hospital, Colombes, France. 9. Sorbonne University, Paris, France; Department of Obstetrics and Gynecology, AP-HP, Necker Enfant Malade Hospital, Paris, France. 10. Université de Paris, INSERM UMR1266, Institute of Psychiatry and Neurosciences, Team 1, Paris, France. 11. Sorbonne University, Paris, France; INSERM, Institut Pierre Louis D'Epidémiologie et de Santé Publique IPLESP, AP-HP, Hôpitaux Universitaires Pitié Salpêtrière - Charles Foix, F75013, Paris, France. 12. Department of Epidemiology, Biostatistics and Clinical Research, AP-HP, Hôpital Bichat, F-75018, Paris, France; Université de Paris, IAME, INSERM, F-75018 Paris, France.
Abstract
BACKGROUND: IGEDEPP (Interaction of Gene and Environment of Depression during PostPartum) is a prospective multicenter cohort study of 3310 Caucasian women who gave birth between 2011 and 2016, with follow-up until one year postpartum. The aim of the current study is to describe the cohort and estimate the prevalence and cumulative incidence of early and late-onset postpartum depression (PPD). METHODS: Socio-demographic data, personal and family psychiatric history, as well as stressful life events during childhood and pregnancy were evaluated at baseline. Early and late-onset PPD were assessed at 8 weeks and 1 year postpartum respectively, using DSM-5 criteria. RESULTS: The prevalence of early-onset PPD was 8.3% (95%CI 7.3-9.3), and late PPD 12.9% (95%CI 11.5-14.2), resulting in an 8-week cumulative incidence of 8.5% (95%CI 7.4-9.6) and a one-year cumulative incidence of PPD of 18.1% (95%CI: 17.1-19.2). Nearly half of the cohort (N = 1571, 47.5%) had a history of at least one psychiatric or addictive disorder, primarily depressive disorder (35%). Almost 300 women in the cohort (9.0%) reported childhood trauma. During pregnancy, 47.7% women experienced a stressful event, 30.2% in the first 8 weeks and 43.9% between 8 weeks and one year postpartum. Nearly one in five women reported at least one stressful postpartum event at 8 weeks. CONCLUSION: Incident depressive episodes affected nearly one in five women during the first year postpartum. Most women had stressful perinatal events. Further IGEDEPP studies will aim to disentangle the impact of childhood and pregnancy-related stressful events on postpartum mental disorders.
BACKGROUND: IGEDEPP (Interaction of Gene and Environment of Depression during PostPartum) is a prospective multicenter cohort study of 3310 Caucasian women who gave birth between 2011 and 2016, with follow-up until one year postpartum. The aim of the current study is to describe the cohort and estimate the prevalence and cumulative incidence of early and late-onset postpartum depression (PPD). METHODS: Socio-demographic data, personal and family psychiatric history, as well as stressful life events during childhood and pregnancy were evaluated at baseline. Early and late-onset PPD were assessed at 8 weeks and 1 year postpartum respectively, using DSM-5 criteria. RESULTS: The prevalence of early-onset PPD was 8.3% (95%CI 7.3-9.3), and late PPD 12.9% (95%CI 11.5-14.2), resulting in an 8-week cumulative incidence of 8.5% (95%CI 7.4-9.6) and a one-year cumulative incidence of PPD of 18.1% (95%CI: 17.1-19.2). Nearly half of the cohort (N = 1571, 47.5%) had a history of at least one psychiatric or addictive disorder, primarily depressive disorder (35%). Almost 300 women in the cohort (9.0%) reported childhood trauma. During pregnancy, 47.7% women experienced a stressful event, 30.2% in the first 8 weeks and 43.9% between 8 weeks and one year postpartum. Nearly one in five women reported at least one stressful postpartum event at 8 weeks. CONCLUSION: Incident depressive episodes affected nearly one in five women during the first year postpartum. Most women had stressful perinatal events. Further IGEDEPP studies will aim to disentangle the impact of childhood and pregnancy-related stressful events on postpartum mental disorders.
Authors: Michael O Schneider; Jutta Pretscher; Tamme W Goecke; Lothar Häberle; Anne Engel; Johannes Kornhuber; Anna Eichler; Arif B Ekici; Matthias W Beckmann; Peter A Fasching; Eva Schwenke Journal: Arch Gynecol Obstet Date: 2022-06-10 Impact factor: 2.344
Authors: Marta Nicolás-López; Pablo González-Álvarez; Anna Sala de la Concepción; Paula Sol Ventura Wichner; Gemma Ginovart; Maria Giralt-López; Beatriz Lorente; Inés Velasco Journal: BMC Pregnancy Childbirth Date: 2022-09-26 Impact factor: 3.105