Literature DB >> 3393262

Evidence to suggest that the spontaneous release of acetylcholine from rat hippocampal tissue is carrier-mediated.

M T Ivy1, P T Carroll.   

Abstract

The effect of L- and D-stereoisomers of 2-(4-phenylpiperidino) cyclohexanol (AH 5183) on the spontaneous release of acetylcholine (ACh) from rat hippocampal tissue was studied. L-AH 5183 was approximately 100 times more potent than was D-AH 5183 in reducing spontaneous ACh release. Spontaneous ACh release was also temperature dependent. These results may suggest that the spontaneous release of ACh from brain tissue is carrier-mediated.

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Year:  1988        PMID： 3393262     DOI： 10.1007/bf00972481

Source DB:  PubMed          Journal:  Neurochem Res        ISSN： 0364-3190            Impact factor:   3.996


  24 in total

1.  Relative importance of choline transport to spontaneous and potassium depolarized release of ACh.

Authors:  P T Carroll; A M Goldberg
Journal:  J Neurochem       Date:  1975-10       Impact factor: 5.372

2.  Neurotrophic regulation of two properties of skeletal muscle by impulse-dependent and spontaneous acetylcholine transmission.

Authors:  D B Drachman; E F Stanley; A Pestronk; J W Griffin; D L Price
Journal:  J Neurosci       Date:  1982-02       Impact factor: 6.167

3.  Spontaneous and potassium-induced release of acetylcholine from mouse forebrain minces.

Authors:  P T Carroll; J A Aspry
Journal:  Neuroscience       Date:  1981       Impact factor: 3.590

4.  Subcellular origin of cholinergic transmitter release from mouse brain.

Authors:  P T Carroll; J M Aspry
Journal:  Science       Date:  1980-11-07       Impact factor: 47.728

5.  Veratridine-induced breakdown of cytosolic acetylcholine in rat hippocampal minces: an intraterminal form of acetylcholinesterase or choline O-acetyltransferase?

Authors:  P T Carroll; M Badamchian; P Craig; W H Lyness
Journal:  Brain Res       Date:  1986-09-24       Impact factor: 3.252

6.  Does the motor nerve impulse evoke 'non-quantal' transmitter release?

Authors:  B Katz; R Miledi
Journal:  Proc R Soc Lond B Biol Sci       Date:  1981-05-07

7.  Depolarization of mouse forebrain minces with veratridine and high K+: failure to stimulate the Ca2+ independent, spontaneous release of acetylcholine from the cytoplasm due to hydrolysis of the acetylcholine stored there.

Authors:  P T Carroll; C G Benishin
Journal:  Brain Res       Date:  1984-01-23       Impact factor: 3.252

8.  Quantitative autoradiography of brain binding sites for the vesicular acetylcholine transport blocker 2-(4-phenylpiperidino)cyclohexanol (AH5183).

Authors:  M R Marien; S M Parsons; C A Altar
Journal:  Proc Natl Acad Sci U S A       Date:  1987-02       Impact factor: 11.205

9.  Evidence for the role of non-quantal acetylcholine in the maintenance of the membrane potential of rat skeletal muscle.

Authors:  J J Bray; J W Forrest; J I Hubbard
Journal:  J Physiol       Date:  1982-05       Impact factor: 5.182

10.  Veratridine-induced release of acetylcholine from mouse forebrain minces: dependence on the hydrolysis of cytoplasmic acetylcholine for a source of choline.

Authors:  P T Carroll
Journal:  Brain Res       Date:  1984-10-29       Impact factor: 3.252
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