Tauben Averbuch1,2, Shun Fu Lee2, Mamas Andreas Mamas3, Urun Erbas Oz4, Richard Perez4, Stuart James Connolly1,2, Dennis Tien-Wei Ko5,6, Harriette Gillian Christine Van Spall1,2,4,7. 1. Department of Medicine, McMaster University, Hamilton, Ontario, Canada. 2. Population Health Research Institute, Hamilton, Ontario, Canada. 3. Department of Cardiology, Keele University, Keele, UK. 4. ICES, Hamilton, Ontario, Canada. 5. Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. 6. ICES, Toronto, Ontario, Canada. 7. Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.
Abstract
BACKGROUND: The LACE index-length of stay (L), acuity (A), Charlson co-morbidities (C), and emergent visits (E)-predicts 30-day outcomes following heart failure (HF) hospitalization but is complex to score. A simpler LE index (length of stay and emergent visits) could offer a practical advantage in point-of-care risk prediction. METHODS AND RESULTS: This was a sub-study of the patient-centred care transitions in HF (PACT-HF) multicentre trial. The derivation cohort comprised patients hospitalized for HF, enrolled in the trial, and followed prospectively. External validation was performed retrospectively in a cohort of patients hospitalized for HF. We used log-binomial regression models with LACE or LE as the predictor and either 30-day composite all-cause readmission or death or 30-day all-cause readmission as the outcomes, adjusting only for post-discharge services. There were 1985 patients (mean [SD] age 78.1 [12.1] years) in the derivation cohort and 378 (mean [SD] age 73.1 [13.2] years) in the validation cohort. Increments in the LACE and LE indices were associated with 17% (RR 1.17; 95% CI 1.12, 1.21; C-statistic 0.64) and 21% (RR 1.21; 95% CI 1.15, 1.26; C-statistic 0.63) increases, respectively, in 30-day composite all-cause readmission or death; and 16% (RR 1.16; 95% CI 1.11, 1.20; C-statistic 0.64) and 18% (RR 1.18; 95% CI 1.13, 1.24; C-statistic 0.62) increases, respectively, in 30-day all-cause readmission. The LE index provided better risk discrimination for the 30-day outcomes than did the LACE index in the external validation cohort. CONCLUSIONS: The LE index predicts 30-day outcomes following HF hospitalization with similar or better performance than the more complex LACE index.
BACKGROUND: The LACE index-length of stay (L), acuity (A), Charlson co-morbidities (C), and emergent visits (E)-predicts 30-day outcomes following heart failure (HF) hospitalization but is complex to score. A simpler LE index (length of stay and emergent visits) could offer a practical advantage in point-of-care risk prediction. METHODS AND RESULTS: This was a sub-study of the patient-centred care transitions in HF (PACT-HF) multicentre trial. The derivation cohort comprised patients hospitalized for HF, enrolled in the trial, and followed prospectively. External validation was performed retrospectively in a cohort of patients hospitalized for HF. We used log-binomial regression models with LACE or LE as the predictor and either 30-day composite all-cause readmission or death or 30-day all-cause readmission as the outcomes, adjusting only for post-discharge services. There were 1985 patients (mean [SD] age 78.1 [12.1] years) in the derivation cohort and 378 (mean [SD] age 73.1 [13.2] years) in the validation cohort. Increments in the LACE and LE indices were associated with 17% (RR 1.17; 95% CI 1.12, 1.21; C-statistic 0.64) and 21% (RR 1.21; 95% CI 1.15, 1.26; C-statistic 0.63) increases, respectively, in 30-day composite all-cause readmission or death; and 16% (RR 1.16; 95% CI 1.11, 1.20; C-statistic 0.64) and 18% (RR 1.18; 95% CI 1.13, 1.24; C-statistic 0.62) increases, respectively, in 30-day all-cause readmission. The LE index provided better risk discrimination for the 30-day outcomes than did the LACE index in the external validation cohort. CONCLUSIONS: The LE index predicts 30-day outcomes following HF hospitalization with similar or better performance than the more complex LACE index.
Authors: Hernan Polo Friz; Valentina Esposito; Giuseppe Marano; Laura Primitz; Alice Bovio; Giovanni Delgrossi; Michele Bombelli; Guido Grignaffini; Giovanni Monza; Patrizia Boracchi Journal: Intern Emerg Med Date: 2022-06-04 Impact factor: 5.472
Authors: Andreas B Gevaert; Semra Tibebu; Mamas A Mamas; Neal G Ravindra; Shun Fu Lee; Tariq Ahmad; Dennis T Ko; James L Januzzi; Harriette G C Van Spall Journal: ESC Heart Fail Date: 2021-05-02