Literature DB >> 33930987

Secoiridoid glycosides from the fruits of Cornus officinalis.

Xin Wang1, Xiang-Jian Zhong1, Na Zhou1, Lin-Lin Ji1, Jin-Jie Li1, Ning Cai1, Qing-Bo Wang1, Peng-Cheng Lin2, Xiao-Ya Shang1.   

Abstract

Five new secoiridoid glycosides, cornusphenosides E-I (1-5), were isolated and characterized from an active fraction of ethanol extract of the fruits of Cornus officinalis. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and HRESIMS experiments. In the preliminary assay, compound 5 (when evaluated at 10 μM) showed the neuroprotective effect against H2O2-induced SH-SY5Y cell damage.

Entities:  

Keywords:  Cornus officinalis; neuroprotective activity; secoiridoid glycosides

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Year:  2020        PMID： 33930987     DOI： 10.1080/14786419.2020.1834547

Source DB:  PubMed          Journal:  Nat Prod Res        ISSN： 1478-6419            Impact factor:   2.861


  3 in total

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Review 2.  Natural drug sources for respiratory diseases from Fritillaria: chemical and biological analyses.

Authors:  Ye Wang; Hongping Hou; Qiang Ren; Haoyu Hu; Tiechui Yang; Xiwen Li
Journal:  Chin Med       Date:  2021-05-31       Impact factor: 5.455

3.  Neocornuside A-D, Four Novel Iridoid Glycosides from Fruits of Cornus officinalis and Their Antidiabetic Activity.

Authors:  Meng Yang; Zhiyou Hao; Xiaolan Wang; Shiqi Zhou; Denghui Zhu; Ying Yang; Junjun Wei; Meng Li; Xiaoke Zheng; Weisheng Feng
Journal:  Molecules       Date:  2022-07-24       Impact factor: 4.927
  3 in total

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