Yuta Hiraike1,2, Chao-Tung Yang3,4,5, Wei-Ju Liu6, Tomohide Yamada7, Chia-Lin Lee6,8,9. 1. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA. 2. Department of Cell Biology, Harvard Medical School , Boston, MA 02115, USA. 3. Department of Computer Science, Tunghai University, Taichung, Taiwan. 4. Research Center for Smart Sustainable Circular Economy, Tunghai University, Taiwan. 5. Research Center for Nanotechnology, Tunghai University, Taiwan. 6. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan. 7. Institute of Population Health, King's College London, London, UK. 8. Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. 9. Department of Medicine, School of Medicine, National Yang-Ming Chiao Tung University, Taipei, Taiwan.
Abstract
CONTEXT: Gene-exercise interaction on cross-sectional body mass index (BMI) has been extensively studied and is well established. However, gene-exercise interaction on changes in body weight/BMI remains controversial. OBJECTIVE: To examine the interaction between the FTO obesity variant and regular exercise on changes in body weight/BMI. PARTICIPANTS: Taiwan Biobank participants aged 30-70 years (N = 20 906) were examined at both baseline and follow-up visit (mean follow-up duration: 3.7 years). MAIN OUTCOME MEASURES: The interaction between the FTO obesity variant rs1421085 and regular exercise habit (no exercise, ≤20 metabolic equivalent of tasks (METs)/week exercise, >20 METs/week exercise) on changes in body weight/BMI. RESULTS: Individuals with the risk allele of rs1421085 gained more weight and increased BMI than those without the risk allele if they did not exercise. In contrast, individuals with the risk allele gained less weight and BMI if they exercised regularly, indicating an interaction between rs1421085 and regular exercise habit (P = .030 for Δbody weight and P = .034 for ΔBMI). The effect of exercise on maintaining body weight was larger in those with the risk allele of rs1421085. When we focused on individuals without regular exercise at baseline, individuals with the risk allele again tended to lose more weight than those with a nonrisk allele if they had acquired an exercise habit by the follow-up visit. CONCLUSION: The beneficial effect of exercise is greater in individuals genetically prone to obesity due to the interaction between the FTO obesity variant rs1421085 and regular exercise on changes in body weight and BMI.
CONTEXT: Gene-exercise interaction on cross-sectional body mass index (BMI) has been extensively studied and is well established. However, gene-exercise interaction on changes in body weight/BMI remains controversial. OBJECTIVE: To examine the interaction between the FTO obesity variant and regular exercise on changes in body weight/BMI. PARTICIPANTS: Taiwan Biobank participants aged 30-70 years (N = 20 906) were examined at both baseline and follow-up visit (mean follow-up duration: 3.7 years). MAIN OUTCOME MEASURES: The interaction between the FTO obesity variant rs1421085 and regular exercise habit (no exercise, ≤20 metabolic equivalent of tasks (METs)/week exercise, >20 METs/week exercise) on changes in body weight/BMI. RESULTS: Individuals with the risk allele of rs1421085 gained more weight and increased BMI than those without the risk allele if they did not exercise. In contrast, individuals with the risk allele gained less weight and BMI if they exercised regularly, indicating an interaction between rs1421085 and regular exercise habit (P = .030 for Δbody weight and P = .034 for ΔBMI). The effect of exercise on maintaining body weight was larger in those with the risk allele of rs1421085. When we focused on individuals without regular exercise at baseline, individuals with the risk allele again tended to lose more weight than those with a nonrisk allele if they had acquired an exercise habit by the follow-up visit. CONCLUSION: The beneficial effect of exercise is greater in individuals genetically prone to obesity due to the interaction between the FTO obesity variant rs1421085 and regular exercise on changes in body weight and BMI.