| Literature DB >> 339284 |
M Okuma, T Yoshimoto, S Yamamoto.
Abstract
The effect on human platelet functions of 9,11-dithio analogues of prostaglandin endoperoxide was investigated. Methyl (5Z, 9alpha, 11alpha, 13E, 15S)-9,11-epidithio-15-hydroxyprosta-5,13-dienoate induced platelet aggregation, while the 9beta,11beta-epimer was inactive. The platelet aggregation caused by the 9alpha,11alpha-dithio analogue was associated with serotonin release from platelets, and was inhibited by methyl ester of prostaglandin I2 (prostacyclin) but not by indomethacin.Entities:
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Year: 1977 PMID： 339284 DOI： 10.1016/0090-6980(77)90305-7
Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980