Literature DB >> 33928357

The mitochondrial landscape of ovarian cancer: emerging insights.

Pallavi Shukla1,2, Keshav K Singh1.   

Abstract

Ovarian cancer (OC) is known to be the most lethal cancer in women worldwide, and its etiology is poorly understood. Recent studies show that mitochondrial DNA (mtDNA) content as well as mtDNA and nuclear genes encoding mitochondrial proteins influence OC risk. This review presents an overview of role of mitochondrial genetics in influencing OC development and discusses the contribution of mitochondrial proteome in OC development, progression and therapy. A role of mitochondrial genetics in racial disparity is also highlighted. In-depth understanding of role of mitochondria in OC will help develop strategies toward prevention and treatment and improving overall survival in women with OC.
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Year:  2021        PMID： 33928357      PMCID： PMC8163040          DOI： 10.1093/carcin/bgab033

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  77 in total

1.  Levels of circulating cell-free nuclear and mitochondrial DNA in benign and malignant ovarian tumors.

Authors:  Rebecca R Zachariah; Seraina Schmid; Nicole Buerki; Ramin Radpour; Wolfgang Holzgreve; Xiaoyan Zhong
Journal:  Obstet Gynecol       Date:  2008-10       Impact factor: 7.661

2.  Genetic polymorphisms in the estrogen receptor beta (ESR2) gene and the risk of epithelial ovarian carcinoma.

Authors:  Galina Lurie; Lynne R Wilkens; Pamela J Thompson; Katharine E McDuffie; Michael E Carney; Keith Y Terada; Marc T Goodman
Journal:  Cancer Causes Control       Date:  2008-08-15       Impact factor: 2.506

3.  Expression of the peroxisome proliferator-activated receptors-alpha, -beta, and -gamma in ovarian carcinoma effusions is associated with poor chemoresponse and shorter survival.

Authors:  Ben Davidson; Rivka Hadar; Helene Tuft Stavnes; Claes G Trope'; Reuven Reich
Journal:  Hum Pathol       Date:  2009-01-20       Impact factor: 3.466

Review 4.  Regulation of mitochondrial biogenesis.

Authors:  François R Jornayvaz; Gerald I Shulman
Journal:  Essays Biochem       Date:  2010       Impact factor: 8.000

5.  Mitochondrial DNA sequence variants in epithelial ovarian tumor subtypes and stages.

Authors:  Felix O Aikhionbare; Sharifeh Mehrabi; K Kumaresan; Mojgan Zavareh; Moshood Olatinwo; Kunle Odunsi; Edward Partridge
Journal:  J Carcinog       Date:  2007-01-26

Review 6.  Antioxidant response elements: Discovery, classes, regulation and potential applications.

Authors:  Azhwar Raghunath; Kiruthika Sundarraj; Raju Nagarajan; Frank Arfuso; Jinsong Bian; Alan P Kumar; Gautam Sethi; Ekambaram Perumal
Journal:  Redox Biol       Date:  2018-05-07       Impact factor: 11.799

7.  Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer.

Authors:  Kelly L Singel; Kassondra S Grzankowski; A N M Nazmul H Khan; Melissa J Grimm; Anthony C D'Auria; Kayla Morrell; Kevin H Eng; Bonnie Hylander; Paul C Mayor; Tiffany R Emmons; Nikolett Lénárt; Rebeka Fekete; Zsuzsanna Környei; Uma Muthukrishnan; Jonathan D Gilthorpe; Constantin F Urban; Kiyoshi Itagaki; Carl J Hauser; Cynthia Leifer; Kirsten B Moysich; Kunle Odunsi; Ádám Dénes; Brahm H Segal
Journal:  Br J Cancer       Date:  2018-12-06       Impact factor: 7.640

8.  Development and validation of SIRT3-related nomogram predictive of overall survival in patients with serous ovarian cancer.

Authors:  Jun Li; Huiran Yue; Hailin Yu; Xin Lu; Xiaohong Xue
Journal:  J Ovarian Res       Date:  2019-05-21       Impact factor: 4.234

9.  mtDNA sequence variants in subtypes of epithelial ovarian cancer stages in relation to ethnic and age difference.

Authors:  Felix O Aikhionbare; Sharifeh Mehrabi; Winston Thompson; Xuebiao Yao; William Grizzle; Edward Partridge
Journal:  Diagn Pathol       Date:  2008-07-28       Impact factor: 2.644

10.  Mitochondrial mRNA transcripts predict overall survival, tumor recurrence and progression in serous ovarian cancer: Companion diagnostics for cancer therapy.

Authors:  Federica Sotgia; Michael P Lisanti
Journal:  Oncotarget       Date:  2017-08-06
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