Christina Thornton1, Ranjani Somayaji1,2,3, Michael Parkins1,2, Mark G Swain1, Kathleen J Ramos4, Christopher H Goss4, Abdel A Shaheen1,2,3. 1. Department of Medicine, Cumming School of Medicine, University of Calgary, Alberta, Canada. 2. Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Alberta, Canada. 3. Department of Community Health Sciences, University of Calgary, Alberta, Canada. 4. Department of Medicine, University of Washington, Seattle, Washington, USA.
Abstract
INTRODUCTION: To describe the characteristics and outcomes of children with cystic fibrosis (CF) hospitalized with cirrhosis in the United States. METHODS: We conducted a population-based cohort study of hospitalizations among children with CF using the 2016 Kid's Inpatient Database. RESULTS: In total, 9,615 admissions were analyzed. Diagnosis of cirrhosis was present in 509 (5.3%) and was significantly associated with increased mortality, length of stay, and hospital charges compared with those without cirrhosis. Hepatic encephalopathy was significantly associated with death in children with cirrhosis. DISCUSSION: Future interventions should be designed to support children with CF who have cirrhosis to improve clinical outcomes.
INTRODUCTION: To describe the characteristics and outcomes of children with cystic fibrosis (CF) hospitalized with cirrhosis in the United States. METHODS: We conducted a population-based cohort study of hospitalizations among children with CF using the 2016 Kid's Inpatient Database. RESULTS: In total, 9,615 admissions were analyzed. Diagnosis of cirrhosis was present in 509 (5.3%) and was significantly associated with increased mortality, length of stay, and hospital charges compared with those without cirrhosis. Hepatic encephalopathy was significantly associated with death in children with cirrhosis. DISCUSSION: Future interventions should be designed to support children with CF who have cirrhosis to improve clinical outcomes.
Authors: Manuel Mendizabal; K Rajender Reddy; James Cassuto; Kim M Olthoff; Thomas W Faust; George A Makar; Elizabeth B Rand; Abraham Shaked; Peter L Abt Journal: Liver Transpl Date: 2011-03 Impact factor: 5.799
Authors: Lauren Lapointe-Shaw; Firass Georgie; David Carlone; Orlando Cerocchi; Hannah Chung; Yvonne Dewit; Jordan J Feld; Laura Holder; Jeffrey C Kwong; Beate Sander; Jennifer A Flemming Journal: PLoS One Date: 2018-08-22 Impact factor: 3.240