Karol Piotr Sagan1, Elżbieta Andrysiak-Mamos1, Ernest Tyburski2, Leszek Michał Sagan3, Anhelli Syrenicz1. 1. Department of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University, 70-204 Szczecin, Poland. 2. Institute of Psychology, SWPS University of Social Sciences and Humanities, 03-815 Poznan, Poland. 3. Department of Neurosurgery, Pomeranian Medical University, 70-204 Szczecin, Poland.
Abstract
OBJECTIVE: To determine the effect of transsphenoidal surgery on quality of life and sleep in patients with pituitary adenomas depending on tumor type and compression of the optic chiasm. METHODS: In this prospective study, patients with pituitary adenomas who were scheduled for transsphenoidal surgery completed the Short Form 36 Questionnaire, Pittsburgh Sleep Quality Index, and Epworth Sleepiness Scale preoperatively and 7.5 (±1.5) months after surgery. Patients were analyzed based on tumor type and compression of the optic chiasm. RESULTS: Significant improvements with large effect sizes were seen for patients with Cushing's disease in general health (Z = -2.37; p = 0.018), vitality (Z = -2.05; p = 0.041), and mental health (Z = -2.06; p = 0.040). A significant deterioration with large effect size occurred in physical functioning (Z = -2.02; p = 0.043) in patients with acromegaly. A significant improvement with medium effect size was seen in subjective sleep quality, (Z = -2.24; p = 0.025), sleep duration (Z = -2.11; p = 0.035), and habitual sleep efficiency (Z = -2.26; p = 0.024) after decompression of the optic chiasm. Multiple significant correlations were observed between sleep parameters and Short Form 36 subscales before and after treatment. CONCLUSIONS: Changes in quality of life during the follow-up period depend on tumor type. Circadian rhythm disturbances may resolve promptly after decompression of the optic chiasm. Quality of life in pituitary adenoma patients is associated with quality of sleep in many dimensions, thus implying that developing strategies to improve sleep quality could increase overall well-being and everyday functioning in pituitary adenoma patients.
OBJECTIVE: To determine the effect of transsphenoidal surgery on quality of life and sleep in patients with pituitary adenomas depending on tumor type and compression of the optic chiasm. METHODS: In this prospective study, patients with pituitary adenomas who were scheduled for transsphenoidal surgery completed the Short Form 36 Questionnaire, Pittsburgh Sleep Quality Index, and Epworth Sleepiness Scale preoperatively and 7.5 (±1.5) months after surgery. Patients were analyzed based on tumor type and compression of the optic chiasm. RESULTS: Significant improvements with large effect sizes were seen for patients with Cushing's disease in general health (Z = -2.37; p = 0.018), vitality (Z = -2.05; p = 0.041), and mental health (Z = -2.06; p = 0.040). A significant deterioration with large effect size occurred in physical functioning (Z = -2.02; p = 0.043) in patients with acromegaly. A significant improvement with medium effect size was seen in subjective sleep quality, (Z = -2.24; p = 0.025), sleep duration (Z = -2.11; p = 0.035), and habitual sleep efficiency (Z = -2.26; p = 0.024) after decompression of the optic chiasm. Multiple significant correlations were observed between sleep parameters and Short Form 36 subscales before and after treatment. CONCLUSIONS: Changes in quality of life during the follow-up period depend on tumor type. Circadian rhythm disturbances may resolve promptly after decompression of the optic chiasm. Quality of life in pituitary adenomapatients is associated with quality of sleep in many dimensions, thus implying that developing strategies to improve sleep quality could increase overall well-being and everyday functioning in pituitary adenomapatients.
Entities:
Keywords:
Cushing’s syndrome; acromegaly; non-functioning pituitary adenoma; pituitary adenoma; quality of life; quality of sleep
Authors: Marek Bolanowski; Marek Ruchała; Wojciech Zgliczyński; Beata Kos-Kudła; Alicja Hubalewska-Dydejczyk; Andrzej Lewiński Journal: Endokrynol Pol Date: 2019 Impact factor: 1.582
Authors: Arturo Vega-Beyhart; Víctor M Enriquez-Estrada; Omar Y Bello-Chavolla; Tania R Torres-Victoria; Froylan D Martínez-Sánchez; Juan M López-Navarro; Mireya C Pérez-Guzmán; Jose M Hinojosa-Amaya; Andrés León-Suárez; Hector D Espinoza-Salazar; Paola Roldán-Sarmiento; Miguel A Gómez-Sámano; Francisco J Gómez-Pérez; Daniel Cuevas-Ramos Journal: Clin Endocrinol (Oxf) Date: 2019-01-15 Impact factor: 3.478
Authors: Laurence Katznelson; Edward R Laws; Shlomo Melmed; Mark E Molitch; Mohammad Hassan Murad; Andrea Utz; John A H Wass Journal: J Clin Endocrinol Metab Date: 2014-10-30 Impact factor: 5.958
Authors: Philippe J Caron; John S Bevan; Stephan Petersenn; Aude Houchard; Caroline Sert; Susan M Webb Journal: Pituitary Date: 2016-04 Impact factor: 4.107
Authors: Aleksandra Jawiarczyk-Przybyłowska; Dorota Szcześniak; Marta Ciułkowicz; Marek Bolanowski; Joanna Rymaszewska Journal: Front Endocrinol (Lausanne) Date: 2020-01-14 Impact factor: 5.555