Literature DB >> 33925691

Role of ABCA7 in Human Health and in Alzheimer's Disease.

Shiraz Dib1, Jens Pahnke2,3,4,5, Fabien Gosselet1.   

Abstract

Several studies, including genome wide association studies (GWAS), have strongly suggested a central role for the ATP-binding cassette transporter subfamily A member 7 (ABCA7) in Alzheimer's disease (AD). This ABC transporter is now considered as an important genetic determinant for late onset Alzheimer disease (LOAD) by regulating several molecular processes such as cholesterol metabolism and amyloid processing and clearance. In this review we shed light on these new functions and their cross-talk, explaining its implication in brain functioning, and therefore in AD onset and development.

Entities:  

Keywords:  ABCA7; Alzheimer’s disease; Aβ peptides; cholesterol; phagocytosis

Year:  2021        PMID： 33925691     DOI： 10.3390/ijms22094603

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  84 in total

1.  Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.

Authors:  Suzanne E Wahrle; Hong Jiang; Maia Parsadanian; Richard E Hartman; Kelly R Bales; Steven M Paul; David M Holtzman
Journal:  J Biol Chem       Date:  2005-10-05       Impact factor: 5.157

2.  The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

Authors:  Veronica Hirsch-Reinshagen; Luis F Maia; Braydon L Burgess; Jean-Francois Blain; Kathryn E Naus; Sean A McIsaac; Pamela F Parkinson; Jennifer Y Chan; Gavin H Tansley; Michael R Hayden; Judes Poirier; William Van Nostrand; Cheryl L Wellington
Journal:  J Biol Chem       Date:  2005-10-05       Impact factor: 5.157

3.  ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain.

Authors:  YuHong Fu; Jen-Hsiang T Hsiao; George Paxinos; Glenda M Halliday; Woojin Scott Kim
Journal:  J Alzheimers Dis       Date:  2016-09-06       Impact factor: 4.472

4.  ABCA7 risk variant in healthy older African Americans is associated with a functionally isolated entorhinal cortex mediating deficient generalization of prior discrimination training.

Authors:  Neha Sinha; Zachariah M Reagh; Nicholas J Tustison; Chelsie N Berg; Ashlee Shaw; Catherine E Myers; Diane Hill; Michael A Yassa; Mark A Gluck
Journal:  Hippocampus       Date:  2018-12-10       Impact factor: 3.899

Review 5.  The ABC subfamily A transporters: Multifaceted players with incipient potentialities in cancer.

Authors:  Michela Pasello; Anna Maria Giudice; Katia Scotlandi
Journal:  Semin Cancer Biol       Date:  2019-10-09       Impact factor: 15.707

Review 6.  Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease.

Authors:  Ian J Martins; Tamar Berger; Matthew J Sharman; Giuseppe Verdile; Stephanie J Fuller; Ralph N Martins
Journal:  J Neurochem       Date:  2009-12       Impact factor: 5.372

7.  Markers of cholesterol transport are associated with amyloid deposition in the brain.

Authors:  Timothy M Hughes; Oscar L Lopez; Rhobert W Evans; M Ilyas Kamboh; Jeff D Williamson; William E Klunk; Chester A Mathis; Julie C Price; Ann D Cohen; Beth E Snitz; Steven T Dekosky; Lewis H Kuller
Journal:  Neurobiol Aging       Date:  2013-10-03       Impact factor: 4.673

Review 8.  The role of ABCA7 in Alzheimer's disease: evidence from genomics, transcriptomics and methylomics.

Authors:  Arne De Roeck; Christine Van Broeckhoven; Kristel Sleegers
Journal:  Acta Neuropathol       Date:  2019-03-22       Impact factor: 17.088

9.  Validation of a priori candidate Alzheimer's disease SNPs with brain amyloid-beta deposition.

Authors:  Michael Vacher; Tenielle Porter; Victor L Villemagne; Lidija Milicic; Madeline Peretti; Christopher Fowler; Ralph Martins; Stephanie Rainey-Smith; David Ames; Colin L Masters; Christopher C Rowe; James D Doecke; Simon M Laws
Journal:  Sci Rep       Date:  2019-11-19       Impact factor: 4.379

10.  ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing.

Authors:  Kanayo Satoh; Sumiko Abe-Dohmae; Shinji Yokoyama; Peter St George-Hyslop; Paul E Fraser
Journal:  J Biol Chem       Date:  2015-08-10       Impact factor: 5.157
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  10 in total

1.  Strategies to gain novel Alzheimer's disease diagnostics and therapeutics using modulators of ABCA transporters.

Authors:  Jens Pahnke; Pablo Bascuñana; Mirjam Brackhan; Katja Stefan; Vigneshwaran Namasivayam; Radosveta Koldamova; Jingyun Wu; Luisa Möhle; Sven Marcel Stefan
Journal:  Free Neuropathol       Date:  2021-12-13

2.  The Big Picture of Neurodegeneration: A Meta Study to Extract the Essential Evidence on Neurodegenerative Diseases in a Network-Based Approach.

Authors:  Nicolas Ruffini; Susanne Klingenberg; Raoul Heese; Susann Schweiger; Susanne Gerber
Journal:  Front Aging Neurosci       Date:  2022-06-27       Impact factor: 5.702

3.  ABC Transporters in Human Diseases: Future Directions and Therapeutic Perspectives.

Authors:  Thomas Falguières
Journal:  Int J Mol Sci       Date:  2022-04-12       Impact factor: 6.208

4.  Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics.

Authors:  Vigneshwaran Namasivayam; Katja Stefan; Jens Pahnke; Sven Marcel Stefan
Journal:  Comput Struct Biotechnol J       Date:  2021-11-27       Impact factor: 7.271

5.  Prediction of Alzheimer's Disease by a Novel Image-Based Representation of Gene Expression.

Authors:  Habil Kalkan; Umit Murat Akkaya; Güldal Inal-Gültekin; Ana Maria Sanchez-Perez
Journal:  Genes (Basel)       Date:  2022-08-08       Impact factor: 4.141

6.  TNF-α and IL-1β Modulate Blood-Brain Barrier Permeability and Decrease Amyloid-β Peptide Efflux in a Human Blood-Brain Barrier Model.

Authors:  Romain Versele; Emmanuel Sevin; Fabien Gosselet; Laurence Fenart; Pietra Candela
Journal:  Int J Mol Sci       Date:  2022-09-06       Impact factor: 6.208

7.  Whole Exome Sequencing Reveals a Novel APOE Mutation in a Patient With Sporadic Early-Onset Alzheimer's Disease.

Authors:  Jaya Bagaria; Yeonsil Moon; Eva Bagyinszky; Kyu Hwan Shim; Seong Soo A An; SangYun Kim; Seol Heui Han
Journal:  Front Neurol       Date:  2022-06-10       Impact factor: 4.086

8.  Scaffold fragmentation and substructure hopping reveal potential, robustness, and limits of computer-aided pattern analysis (C@PA).

Authors:  Vigneshwaran Namasivayam; Katja Silbermann; Jens Pahnke; Michael Wiese; Sven Marcel Stefan
Journal:  Comput Struct Biotechnol J       Date:  2021-05-10       Impact factor: 7.271

Review 9.  The Role of ABC Transporters in Lipid Metabolism and the Comorbid Course of Chronic Obstructive Pulmonary Disease and Atherosclerosis.

Authors:  Stanislav Kotlyarov; Anna Kotlyarova
Journal:  Int J Mol Sci       Date:  2021-06-23       Impact factor: 5.923

Review 10.  Relationship Between Amyloid-β Deposition and Blood-Brain Barrier Dysfunction in Alzheimer's Disease.

Authors:  Dong Wang; Fanglian Chen; Zhaoli Han; Zhenyu Yin; Xintong Ge; Ping Lei
Journal:  Front Cell Neurosci       Date:  2021-07-19       Impact factor: 5.505
  10 in total

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