Sergio Sola-Rodríguez1,2, José Antonio Vargas-Hitos3, Blanca Gavilán-Carrera4, Antonio Rosales-Castillo3, José Mario Sabio3, Alba Hernández-Martínez1,2, Elena Martínez-Rosales1,2, Norberto Ortego-Centeno5, Alberto Soriano-Maldonado1,2. 1. Department of Education, Faculty of Education Sciences, University of Almería, 04120 Almería, Spain. 2. SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, 04120 Almería, Spain. 3. Systemic Autoimmune Diseases Unit, Department of Internal Medicine, Virgen de las Nieves University Hospital, 18014 Granada, Spain. 4. Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18071 Granada, Spain. 5. Systemic Autoimmune Diseases Unit, Department of Internal Medicine, "San Cecilio" University Hospital, 18016 Granada, Spain.
Abstract
This study aimed to examine the association of relative handgrip strength (rHGS) with cardiometabolic disease risk factors in women with systemic lupus erythematosus (SLE). METHODS: Seventy-seven women with SLE (mean age 43.2, SD 13.8) and clinical stability during the previous six months were included. Handgrip strength was assessed with a digital dynamometer and rHGS was defined as absolute handgrip strength (aHGS) divided by body mass index (BMI). We measured blood pressure, markers of lipid and glucose metabolism, inflammation (high sensitivity C-reactive protein [hs-CRP]), arterial stiffness (pulse wave velocity [PWV]), and renal function. A clustered cardiometabolic risk index (z-score) was computed. RESULTS: Pearson's bivariate correlations revealed that higher rHGS was associated with lower systolic blood pressure (SBP), triglycerides, hs-CRP, PWV, and lower clustered cardiometabolic risk (rrange = from -0.43 to -0.23; all p < 0.05). Multivariable linear regression analyses adjusted for age, disease activity (SLEDAI), and accrual damage (SDI) confirmed these results (all p < 0.05) except for triglycerides. CONCLUSIONS: The findings suggest that higher rHGS is significantly associated with lower cardiometabolic risk in women with SLE.
This study aimed to examine the association of relative handgrip strength (rHGS) with cardiometabolic disease risk factors in women with systemic lupus erythematosus (SLE). METHODS: Seventy-seven women with SLE (mean age 43.2, SD 13.8) and clinical stability during the previous six months were included. Handgrip strength was assessed with a digital dynamometer and rHGS was defined as absolute handgrip strength (aHGS) divided by body mass index (BMI). We measured blood pressure, markers of lipid and glucose metabolism, inflammation (high sensitivity C-reactive protein [hs-CRP]), arterial stiffness (pulse wave velocity [PWV]), and renal function. A clustered cardiometabolic risk index (z-score) was computed. RESULTS: Pearson's bivariate correlations revealed that higher rHGS was associated with lower systolic blood pressure (SBP), triglycerides, hs-CRP, PWV, and lower clustered cardiometabolic risk (rrange = from -0.43 to -0.23; all p < 0.05). Multivariable linear regression analyses adjusted for age, disease activity (SLEDAI), and accrual damage (SDI) confirmed these results (all p < 0.05) except for triglycerides. CONCLUSIONS: The findings suggest that higher rHGS is significantly associated with lower cardiometabolic risk in women with SLE.
Entities:
Keywords:
autoimmune disease; body mass index; cardiovascular disease; cardiovascular risk; lupus; metabolism; muscle strength; risk factors
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