Literature DB >> 33924874

Mitochondria Turnover and Lysosomal Function in Hematopoietic Stem Cell Metabolism.

Makiko Mochizuki-Kashio1, Hiroko Shiozaki2, Toshio Suda3,4, Ayako Nakamura-Ishizu1.   

Abstract

Hematopoietic stem cells (HSCs) reside in a hypoxic microenvironment that enables glycolysis-fueled metabolism and reduces oxidative stress. Nonetheless, metabolic regulation in organelles such as the mitochondria and lysosomes as well as autophagic processes have been implicated as essential for the determination of HSC cell fate. This review encompasses the current understanding of anaerobic metabolism in HSCs as well as the emerging roles of mitochondrial metabolism and lysosomal regulation for hematopoietic homeostasis.

Entities:  

Keywords:  ROS; autophagy; folliculin; hematopoietic stem cells; lysosome; mitochondria

Year:  2021        PMID： 33924874     DOI： 10.3390/ijms22094627

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  95 in total

1.  Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.

Authors:  Keiyo Takubo; Go Nagamatsu; Chiharu I Kobayashi; Ayako Nakamura-Ishizu; Hiroshi Kobayashi; Eiji Ikeda; Nobuhito Goda; Yasmeen Rahimi; Randall S Johnson; Tomoyoshi Soga; Atsushi Hirao; Makoto Suematsu; Toshio Suda
Journal:  Cell Stem Cell       Date:  2013-01-03       Impact factor: 24.633

2.  High mitochondrial mass is associated with reconstitution capacity and quiescence of hematopoietic stem cells.

Authors:  Yuji Takihara; Ayako Nakamura-Ishizu; Darren Qiancheng Tan; Masahiro Fukuda; Takayoshi Matsumura; Mitsuhiro Endoh; Yuichiro Arima; Desmond Wai Loon Chin; Terumasa Umemoto; Michihiro Hashimoto; Hidenobu Mizuno; Toshio Suda
Journal:  Blood Adv       Date:  2019-08-13

3.  Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation.

Authors:  Wen-Mei Yu; Xia Liu; Jinhua Shen; Olga Jovanovic; Elena E Pohl; Stanton L Gerson; Toren Finkel; Hal E Broxmeyer; Cheng-Kui Qu
Journal:  Cell Stem Cell       Date:  2013-01-03       Impact factor: 24.633

4.  Fancd2 is required for nuclear retention of Foxo3a in hematopoietic stem cell maintenance.

Authors:  Xiaoli Li; Jie Li; Andrew Wilson; Jared Sipple; Jonathan Schick; Qishen Pang
Journal:  J Biol Chem       Date:  2014-12-12       Impact factor: 5.157

5.  mTORC1 signaling governs hematopoietic stem cell quiescence.

Authors:  Boyi Gan; Ronald A DePinho
Journal:  Cell Cycle       Date:  2009-04-02       Impact factor: 4.534

6.  BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells.

Authors:  Eleni D Lagadinou; Alexander Sach; Kevin Callahan; Randall M Rossi; Sarah J Neering; Mohammad Minhajuddin; John M Ashton; Shanshan Pei; Valerie Grose; Kristen M O'Dwyer; Jane L Liesveld; Paul S Brookes; Michael W Becker; Craig T Jordan
Journal:  Cell Stem Cell       Date:  2013-01-17       Impact factor: 24.633

7.  Oxidative stress-specific interaction between FANCD2 and FOXO3a.

Authors:  Jie Li; Wei Du; Suzette Maynard; Paul R Andreassen; Qishen Pang
Journal:  Blood       Date:  2009-12-29       Impact factor: 22.113

8.  Autophagy maintains the metabolism and function of young and old stem cells.

Authors:  Theodore T Ho; Matthew R Warr; Emmalee R Adelman; Olivia M Lansinger; Johanna Flach; Evgenia V Verovskaya; Maria E Figueroa; Emmanuelle Passegué
Journal:  Nature       Date:  2017-03-01       Impact factor: 49.962

9.  The autophagy Protein Atg5 Plays a Crucial Role in the Maintenance and Reconstitution Ability of Hematopoietic Stem Cells.

Authors:  Hi Eun Jung; Ye Ri Shim; Ji Eun Oh; Dong Sun Oh; Heung Kyu Lee
Journal:  Immune Netw       Date:  2019-02-28       Impact factor: 6.303

10.  Mitochondrial Membrane Potential Identifies Cells with Enhanced Stemness for Cellular Therapy.

Authors:  Madhusudhanan Sukumar; Jie Liu; Gautam U Mehta; Shashank J Patel; Rahul Roychoudhuri; Joseph G Crompton; Christopher A Klebanoff; Yun Ji; Peng Li; Zhiya Yu; Greg D Whitehill; David Clever; Robert L Eil; Douglas C Palmer; Suman Mitra; Mahadev Rao; Keyvan Keyvanfar; David S Schrump; Ena Wang; Francesco M Marincola; Luca Gattinoni; Warren J Leonard; Pawel Muranski; Toren Finkel; Nicholas P Restifo
Journal:  Cell Metab       Date:  2015-12-08       Impact factor: 27.287
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  3 in total

1.  Special Issue: Cellular Oxygen Homeostasis.

Authors:  Verena Tretter
Journal:  Int J Mol Sci       Date:  2022-04-19       Impact factor: 6.208

Review 2.  Increasing Complexity of Molecular Landscapes in Human Hematopoietic Stem and Progenitor Cells during Development and Aging.

Authors:  Suzanne M Watt; Peng Hua; Irene Roberts
Journal:  Int J Mol Sci       Date:  2022-03-27       Impact factor: 5.923

Review 3.  Emerging Evidence of the Significance of Thioredoxin-1 in Hematopoietic Stem Cell Aging.

Authors:  Shaima Jabbar; Parker Mathews; Yubin Kang
Journal:  Antioxidants (Basel)       Date:  2022-06-29
  3 in total

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