Literature DB >> 33924844

Biological Therapy with Complementary and Alternative Medicine in Innocuous Integrative Oncology: A Case of Cervical Cancer.

Elvin Peter Chizenga1, Heidi Abrahamse1.   

Abstract

Good medicine is based on good science, inquiry driven and open to new paradigms. For a complex disease such as cancer, a complex treatment regime that is well structured and multifactorial is indispensable. In the present day, Complementary and Alternative Medicine (CAM) therapies are being used frequently for cancer, alongside modern biological therapies and allopathic medicine, in what is called integrative oncology. In all conscience, the use of natural, less invasive interventions whenever possible is ideal. However, a comprehensive understanding of not only the etiopathology of individual cancers, but also the detailed genetic and epigenetic characteristics, the cancer hallmarks, that clearly show the blueprint of the cancer phenotype is a requisite. Different tumors have a common behavioral pattern, but their specific features at the genetic and epigenetic levels vary to a great extent. Henceforth, with so many failed attempts to therapy, drug formulations and combinations need a focused pre-assessment of the inherent features of individual cancers to destroy the tumors holistically by targeting these features. This review therefore presents innocuous therapeutic regimes by means of CAM and integrative medicine approaches that can specifically target the hallmarks of cancer, using the case of cervical cancer.

Entities:  

Keywords:  biological therapy; cancer hallmarks; cervical cancer; human papillomavirus (HPV); integrative medicine; nutraceuticals; oncoproteins; tumor-associated antigens (TAAs)

Year:  2021        PMID: 33924844     DOI: 10.3390/pharmaceutics13050626

Source DB:  PubMed          Journal:  Pharmaceutics        ISSN: 1999-4923            Impact factor:   6.321


  92 in total

Review 1.  Human papillomavirus testing in the prevention of cervical cancer.

Authors:  Mark Schiffman; Nicolas Wentzensen; Sholom Wacholder; Walter Kinney; Julia C Gage; Philip E Castle
Journal:  J Natl Cancer Inst       Date:  2011-01-31       Impact factor: 13.506

Review 2.  Role of music therapy in integrative oncology.

Authors:  Lucanne Magill
Journal:  J Soc Integr Oncol       Date:  2006

3.  Immune checkpoint Ab enhances the antigen-specific anti-tumor effects by modulating both dendritic cells and regulatory T lymphocytes.

Authors:  Nai-Yun Sun; Yu-Li Chen; Han-Wei Lin; Ying-Cheng Chiang; Chi-Fang Chang; Yi-Jou Tai; Chi-An Chen; Wei-Zen Sun; Chung-Liang Chien; Wen-Fang Cheng
Journal:  Cancer Lett       Date:  2018-12-10       Impact factor: 8.679

4.  Paclitaxel and cisplatin as first-line therapy in recurrent or advanced squamous cell carcinoma of the cervix: a gynecologic oncology group study.

Authors:  P G Rose; J A Blessing; D M Gershenson; R McGehee
Journal:  J Clin Oncol       Date:  1999-09       Impact factor: 44.544

5.  Acupuncture for hot flashes in patients with prostate cancer.

Authors:  Tomasz M Beer; Maria Benavides; Sandra L Emmons; Margaret Hayes; Guohui Liu; Mark Garzotto; Deirdre Donovan; Nina Katovic; Caron Reeder; Kristine Eilers
Journal:  Urology       Date:  2010-05-21       Impact factor: 2.649

6.  Oridonin induces apoptosis via PI3K/Akt pathway in cervical carcinoma HeLa cell line.

Authors:  Hong-zhen Hu; Yue-bo Yang; Xiang-dong Xu; Hong-wei Shen; Yi-min Shu; Zi Ren; Xiao-mao Li; Hui-ming Shen; Hai-tao Zeng
Journal:  Acta Pharmacol Sin       Date:  2007-11       Impact factor: 6.150

7.  Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens.

Authors:  Sjoerd H van der Burg; Sytse J Piersma; Annemieke de Jong; Jeanette M van der Hulst; Kitty M C Kwappenberg; Muriel van den Hende; Marij J P Welters; Jon J Van Rood; Gert Jan Fleuren; Cornelis J M Melief; Gemma G Kenter; Rienk Offringa
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-05       Impact factor: 11.205

8.  Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.

Authors:  Freddie Bray; Jacques Ferlay; Isabelle Soerjomataram; Rebecca L Siegel; Lindsey A Torre; Ahmedin Jemal
Journal:  CA Cancer J Clin       Date:  2018-09-12       Impact factor: 508.702

9.  THE METABOLISM OF TUMORS IN THE BODY.

Authors:  O Warburg; F Wind; E Negelein
Journal:  J Gen Physiol       Date:  1927-03-07       Impact factor: 4.086

Review 10.  CTLA-4 in Regulatory T Cells for Cancer Immunotherapy.

Authors:  Navid Sobhani; Dana Rae Tardiel-Cyril; Aram Davtyan; Daniele Generali; Raheleh Roudi; Yong Li
Journal:  Cancers (Basel)       Date:  2021-03-22       Impact factor: 6.639

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