Literature DB >> 3392390

Ultrastructural aspects of the goiter in cog/cog mice.

A Mayerhofer1, A G Amador, W G Beamer, A Bartke.   

Abstract

Thyroids of congenitally goitrous (cog/cog) mice were studied with light and electron microscopy. The principal alteration in follicular cells was their largely overdistended rough endoplasmic reticulum (RER). Our findings resemble the ultrastructural features of human hypothyroid goiter caused by a thyroglobulin (TG) defect and thus support the previously suggested abnormalities of TG synthesis and/or processing in cog/cog mice.

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Year:  1988        PMID： 3392390     DOI： 10.1093/oxfordjournals.jhered.a110492

Source DB:  PubMed          Journal:  J Hered        ISSN： 0022-1503            Impact factor:   2.645


  11 in total

Review 1.  Lessons from animal models of endocrine disorders caused by defects of protein folding in the secretory pathway.

Authors:  Yoshiaki Morishita; Peter Arvan
Journal:  Mol Cell Endocrinol       Date:  2019-10-09       Impact factor: 4.102

2.  Intracellular transport, assembly, and degradation of wild-type and disease-linked mutant gap junction proteins.

Authors:  J K VanSlyke; S M Deschenes; L S Musil
Journal:  Mol Biol Cell       Date:  2000-06       Impact factor: 4.138

3.  A single amino acid change in the acetylcholinesterase-like domain of thyroglobulin causes congenital goiter with hypothyroidism in the cog/cog mouse: a model of human endoplasmic reticulum storage diseases.

Authors:  P S Kim; S A Hossain; Y N Park; I Lee; S E Yoo; P Arvan
Journal:  Proc Natl Acad Sci U S A       Date:  1998-08-18       Impact factor: 11.205

Review 4.  Thyroglobulin From Molecular and Cellular Biology to Clinical Endocrinology.

Authors:  Bruno Di Jeso; Peter Arvan
Journal:  Endocr Rev       Date:  2015-11-23       Impact factor: 19.871

5.  Defective protein folding and intracellular retention of thyroglobulin-R19K mutant as a cause of human congenital goiter.

Authors:  Paul S Kim; Jaemin Lee; Piyanuch Jongsamak; Shekar Menon; Bailing Li; Shaikh A Hossain; Jin-Ho Bae; Bhinyo Panijpan; Peter Arvan
Journal:  Mol Endocrinol       Date:  2007-10-04

6.  Microcephalic cerebrum with hypomyelination in the congenital goiter mouse (cog).

Authors:  T Sugisaki; W G Beamer; T Noguchi
Journal:  Neurochem Res       Date:  1992-10       Impact factor: 3.996

7.  Cell death-associated lipid droplet protein CIDE-A is a noncanonical marker of endoplasmic reticulum stress.

Authors:  Yoshiaki Morishita; Aaron P Kellogg; Dennis Larkin; Wei Chen; Suryakiran Vadrevu; Leslie Satin; Ming Liu; Peter Arvan
Journal:  JCI Insight       Date:  2021-04-08

8.  Proceedings of the 2013 Joint JSTP/NTP Satellite Symposium.

Authors:  Susan A Elmore; Mark Hoenerhoff; Osamu Katsuta; Hiroko Kokoshima; Robert Maronpot; Hiroaki Nagai; Hiroshi Satoh; Yasuhiro Tanaka; Tomoaki Tochitani; Seiichiro Tsuchiya; Katsuhiko Yoshizawa
Journal:  J Toxicol Pathol       Date:  2013-07-10       Impact factor: 1.628

9.  Spontaneous vacuolar degeneration of the thyroid follicular epithelium in cynomolgus monkeys.

Authors:  Hirofumi Hatakeyama; Yoshihiro Takei; Yumiko Cruz; Seiji Miyoshi; Jun Watanabe; Haruko Koizumi; Akihito Shimoi; Hiroshi Satoh
Journal:  J Toxicol Pathol       Date:  2012-01-07       Impact factor: 1.628

10.  Thyroid hormone synthesis continues despite biallelic thyroglobulin mutation with cell death.

Authors:  Xiaohan Zhang; Aaron P Kellogg; Cintia E Citterio; Hao Zhang; Dennis Larkin; Yoshiaki Morishita; Héctor M Targovnik; Viviana A Balbi; Peter Arvan
Journal:  JCI Insight       Date:  2021-06-08
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