Literature DB >> 33923028

Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities.

Wamidh H Talib1, Ahmad Riyad Alsayed1, Alaa Abuawad2, Safa Daoud3, Asma Ismail Mahmod1.   

Abstract

Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and experimental studies have documented that melatonin could inhibit different types of cancer in vitro and in vivo. Results showed the involvement of melatonin in different anticancer mechanisms including apoptosis induction, cell proliferation inhibition, reduction in tumor growth and metastases, reduction in the side effects associated with chemotherapy and radiotherapy, decreasing drug resistance in cancer therapy, and augmentation of the therapeutic effects of conventional anticancer therapies. Clinical trials revealed that melatonin is an effective adjuvant drug to all conventional therapies. This review summarized melatonin biosynthesis, availability from natural sources, metabolism, bioavailability, anticancer mechanisms of melatonin, its use in clinical trials, and pharmaceutical formulation. Studies discussed in this review will provide a solid foundation for researchers and physicians to design and develop new therapies to treat and prevent cancer using melatonin.

Entities:  

Keywords:  anticancer; cancer therapy; hormonal therapy; phytomelatonin; pineal gland

Year:  2021        PMID： 33923028     DOI： 10.3390/molecules26092506

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  290 in total

Review 1.  MT1 and MT2 Melatonin Receptors: A Therapeutic Perspective.

Authors:  Jiabei Liu; Shannon J Clough; Anthony J Hutchinson; Ekue B Adamah-Biassi; Marina Popovska-Gorevski; Margarita L Dubocovich
Journal:  Annu Rev Pharmacol Toxicol       Date:  2015-10-23       Impact factor: 13.820

2.  Melatonin enhances the apoptotic effects and modulates the changes in gene expression induced by docetaxel in MCF‑7 human breast cancer cells.

Authors:  Carolina Alonso-González; Javier Menéndez-Menéndez; Alicia González-González; Alicia González; Samuel Cos; Carlos Martínez-Campa
Journal:  Int J Oncol       Date:  2017-11-28       Impact factor: 5.650

3.  Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

Authors:  Shideng Bao; Qiulian Wu; Roger E McLendon; Yueling Hao; Qing Shi; Anita B Hjelmeland; Mark W Dewhirst; Darell D Bigner; Jeremy N Rich
Journal:  Nature       Date:  2006-10-18       Impact factor: 49.962

4.  Melatonin attenuates methotrexate-induced oxidative stress and renal damage in rats.

Authors:  Premila Abraham; Viswa Kalyan Kolli; Suganthy Rabi
Journal:  Cell Biochem Funct       Date:  2010-07       Impact factor: 3.685

5.  Pharmacokinetics and oral bioavailability of exogenous melatonin in preclinical animal models and clinical implications.

Authors:  K Yeleswaram; L G McLaughlin; J O Knipe; D Schabdach
Journal:  J Pineal Res       Date:  1997-01       Impact factor: 13.007

Review 6.  Is there a role for melatonin in supportive care?

Authors:  P Lissoni
Journal:  Support Care Cancer       Date:  2001-11-13       Impact factor: 3.603

7.  Preconditioning with melatonin improves therapeutic outcomes of bone marrow-derived mesenchymal stem cells in targeting liver fibrosis induced by CCl4.

Authors:  Keywan Mortezaee; Neda Khanlarkhani; Fatemeh Sabbaghziarani; Saeid Nekoonam; Jamal Majidpoor; Amir Hosseini; Parichehr Pasbakhsh; Iraj Ragerdi Kashani; Adib Zendedel
Journal:  Cell Tissue Res       Date:  2017-04-17       Impact factor: 5.249

8.  Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells.

Authors:  Zhenlong Yu; Xiangge Tian; Yuling Peng; Zheng Sun; Chao Wang; Ning Tang; Bin Li; Yuqing Jian; Wei Wang; Xiaokui Huo; Xiaochi Ma
Journal:  J Pineal Res       Date:  2018-03-25       Impact factor: 13.007

9.  Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation.

Authors:  Tahir Ali; Shafiq Ur Rahman; Qiang Hao; Weifen Li; Zizhen Liu; Fawad Ali Shah; Iram Murtaza; Zaijun Zhang; Xifei Yang; Gongping Liu; Shupeng Li
Journal:  J Pineal Res       Date:  2020-05-06       Impact factor: 13.007

10.  A restricted cell population propagates glioblastoma growth after chemotherapy.

Authors:  Jian Chen; Yanjiao Li; Tzong-Shiue Yu; Renée M McKay; Dennis K Burns; Steven G Kernie; Luis F Parada
Journal:  Nature       Date:  2012-08-23       Impact factor: 49.962
View more
  16 in total

1.  Radiomitigation by Melatonin in C57BL/6 Mice: Possible Implications as Adjuvant in Radiotherapy and Chemotherapy.

Authors:  Akanchha Mani Tripathi; Shahanshah Khan; Nabo Kumar Chaudhury
Journal:  In Vivo       Date:  2022 May-Jun       Impact factor: 2.406

2.  Melatonin induces apoptosis and cell cycle arrest in cervical cancer cells via inhibition of NF-κB pathway.

Authors:  Tarun Minocha; Megha Das; Vipin Rai; Sumit Singh Verma; Nikee Awasthee; Subash Chandra Gupta; Chandana Haldar; Sanjeev Kumar Yadav
Journal:  Inflammopharmacology       Date:  2022-04-17       Impact factor: 5.093

3.  Melatonin Modulation of Radiation-Induced Molecular Changes in MCF-7 Human Breast Cancer Cells.

Authors:  Carolina Alonso-González; Cristina González-Abalde; Javier Menéndez-Menéndez; Alicia González-González; Virginia Álvarez-García; Alicia González-Cabeza; Carlos Martínez-Campa; Samuel Cos
Journal:  Biomedicines       Date:  2022-05-07

Review 4.  Melatonin and Pathological Cell Interactions: Mitochondrial Glucose Processing in Cancer Cells.

Authors:  Russel J Reiter; Ramaswamy Sharma; Sergio Rosales-Corral; Walter Manucha; Luiz Gustavo de Almeida Chuffa; Debora Aparecida Pires de Campos Zuccari
Journal:  Int J Mol Sci       Date:  2021-11-19       Impact factor: 5.923

Review 5.  Nanotechnology Frontiers in γ-Herpesviruses Treatments.

Authors:  Marisa Granato
Journal:  Int J Mol Sci       Date:  2021-10-22       Impact factor: 5.923

Review 6.  Melatonin: Regulation of Prion Protein Phase Separation in Cancer Multidrug Resistance.

Authors:  Doris Loh; Russel J Reiter
Journal:  Molecules       Date:  2022-01-21       Impact factor: 4.411

Review 7.  Use of Melatonin in Cancer Treatment: Where Are We?

Authors:  Leilei Wang; Chuan Wang; Wing Shan Choi
Journal:  Int J Mol Sci       Date:  2022-03-29       Impact factor: 5.923

Review 8.  Impact of Circadian Rhythms on the Development and Clinical Management of Genitourinary Cancers.

Authors:  Priya Kaur; Nihal E Mohamed; Maddison Archer; Mariana G Figueiro; Natasha Kyprianou
Journal:  Front Oncol       Date:  2022-03-09       Impact factor: 6.244

9.  Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing.

Authors:  Beata Kaczmarek-Szczepańska; Justyna Ostrowska; Justyna Kozłowska; Zofia Szota; Anna A Brożyna; Rita Dreier; Russel J Reiter; Andrzej T Slominski; Kerstin Steinbrink; Konrad Kleszczyński
Journal:  Int J Mol Sci       Date:  2021-05-26       Impact factor: 5.923

Review 10.  Exercise-induced oxidative stress and melatonin supplementation: current evidence.

Authors:  Joanna Kruk; Basil Hassan Aboul-Enein; Ewa Duchnik
Journal:  J Physiol Sci       Date:  2021-09-01       Impact factor: 2.781
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.